Dysregulated biosynthesis and hydrolysis of cyclic-di-adenosine monophosphate impedes sporulation and butanol and acetone production in Clostridium beijerinckii NCIMB 8052

Dysregulated biosynthesis and hydrolysis of cyclic-di-adenosine monophosphate impedes sporulation and butanol and acetone production in Clostridium beijerinckii NCIMB 8052

IntroductionAlthough solventogenic Clostridium species (SCS) produce butanol, achieving high enough titers to warrant commercialization of biobutanol remains elusive. Thus, deepening our understanding of the intricate cellular wiring of SCS is crucial to unearthing new targets and strategies for eng...

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Bibliographic Details
Main Authors: Marian M. Awaga-Cromwell, Santosh Kumar, Hieu M. Truong, Eric Agyeman-Duah, Christopher C. Okonkwo, Victor C. Ujor
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
cyclic-di-adenosine monophosphate
butanol
sporulation
solventogenic clostridia
DNA integrity scanning protein A
phosphodiesterase
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1547226/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1547226/full

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