Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators

Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators

Summary: Cystic fibrosis (CF) is a life-shortening disease affecting >160,000 individuals worldwide predominantly with respiratory symptoms. About 80% of individuals with CF have the p.Phe508del variant that causes the CF transmembrane conductance regulator (CFTR) protein to misfold and be target...

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Main Authors: Hugo M. Botelho, Miquéias Lopes-Pacheco, Madalena C. Pinto, Violeta Railean, Ines Pankonien, Mariana F. Caleiro, Luka A. Clarke, Vasco Cachatra, Beate Neumann, Christian Tischer, Cristina Moiteiro, Jiraporn Ousingsawat, Karl Kunzelmann, Rainer Pepperkok, Margarida D. Amaral
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:iScience
Subjects:
Cell biology
Functional genomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225002020
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http://www.sciencedirect.com/science/article/pii/S2589004225002020

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