Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis
Smoking is a well-known major risk factor in development of esophageal cancer, but few studies have reported the association between smoking status and prognosis of these patients. We conduct the present study to summarize current evidence. A computerized search of the PubMed and EMBASE was performe...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/7682387 |
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| author | Jun-jie Kuang Zhi-min Jiang Yan-xian Chen Wei-peng Ye Qiong Yang Hui-zhong Wang De-rong Xie |
| author_facet | Jun-jie Kuang Zhi-min Jiang Yan-xian Chen Wei-peng Ye Qiong Yang Hui-zhong Wang De-rong Xie |
| author_sort | Jun-jie Kuang |
| collection | DOAJ |
| description | Smoking is a well-known major risk factor in development of esophageal cancer, but few studies have reported the association between smoking status and prognosis of these patients. We conduct the present study to summarize current evidence. A computerized search of the PubMed and EMBASE was performed up to April 30, 2015. Eight studies, containing 4,286 patients, were analyzed. In the grouping analysis, among esophageal squamous-cell carcinoma patients, current and former smokers, compared to those who have never smoked, seemed to have a poorer prognosis (HR = 1.41, 95% CI 1.22–1.64, and HR = 1.35, 95% CI 0.92–1.97, resp.). In the subgroup analysis, adverse effects on current smoker compared with never smoker were also observed in China and the other countries (HR = 1.5, 95% CI 1.18–1.92, and HR = 1.36, 95% CI 1.12–1.65, resp.). In the group that ever smoked, we could not get a similar result. No significantly increased risk was found in esophageal adenocarcinoma patients compared to the squamous-cell histology ones. In the smoking intensity analysis, heavy smoking was associated with poor survival in esophageal squamous-cell carcinoma. Our pooled results supported the existence of harmful effects of smoking on survival after esophagus cancer diagnosis. |
| format | Article |
| id | doaj-art-2b923f3c6bc74d20a14818472568a770 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-2b923f3c6bc74d20a14818472568a7702025-02-03T00:59:21ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/76823877682387Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-AnalysisJun-jie Kuang0Zhi-min Jiang1Yan-xian Chen2Wei-peng Ye3Qiong Yang4Hui-zhong Wang5De-rong Xie6Department of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaDepartment of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaDepartment of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaDepartment of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaDepartment of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaDepartment of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaDepartment of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, ChinaSmoking is a well-known major risk factor in development of esophageal cancer, but few studies have reported the association between smoking status and prognosis of these patients. We conduct the present study to summarize current evidence. A computerized search of the PubMed and EMBASE was performed up to April 30, 2015. Eight studies, containing 4,286 patients, were analyzed. In the grouping analysis, among esophageal squamous-cell carcinoma patients, current and former smokers, compared to those who have never smoked, seemed to have a poorer prognosis (HR = 1.41, 95% CI 1.22–1.64, and HR = 1.35, 95% CI 0.92–1.97, resp.). In the subgroup analysis, adverse effects on current smoker compared with never smoker were also observed in China and the other countries (HR = 1.5, 95% CI 1.18–1.92, and HR = 1.36, 95% CI 1.12–1.65, resp.). In the group that ever smoked, we could not get a similar result. No significantly increased risk was found in esophageal adenocarcinoma patients compared to the squamous-cell histology ones. In the smoking intensity analysis, heavy smoking was associated with poor survival in esophageal squamous-cell carcinoma. Our pooled results supported the existence of harmful effects of smoking on survival after esophagus cancer diagnosis.http://dx.doi.org/10.1155/2016/7682387 |
| spellingShingle | Jun-jie Kuang Zhi-min Jiang Yan-xian Chen Wei-peng Ye Qiong Yang Hui-zhong Wang De-rong Xie Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis Gastroenterology Research and Practice |
| title | Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis |
| title_full | Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis |
| title_fullStr | Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis |
| title_short | Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis |
| title_sort | smoking exposure and survival of patients with esophagus cancer a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2016/7682387 |
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