Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion
Objective. The inhalation anesthetic sevoflurane has presented numerous biological activities, including anti-inflammatory properties and protective effects against tissue ischemic injury. This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postcondit...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/5758984 |
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| author | Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Cinthia Lanchotte Ana Maria Mendonça Coelho Mauro Nakatani Eduardo Ryoiti Tatebe Jonathan Augusto Venceslau Lima Camilla Oliveira Mendes Bruno Camargo Rocha Paim de Araujo Emilio Elias Abdo Luiz Carneiro D’Albuquerque Flavio Henrique Ferreira Galvão |
| author_facet | Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Cinthia Lanchotte Ana Maria Mendonça Coelho Mauro Nakatani Eduardo Ryoiti Tatebe Jonathan Augusto Venceslau Lima Camilla Oliveira Mendes Bruno Camargo Rocha Paim de Araujo Emilio Elias Abdo Luiz Carneiro D’Albuquerque Flavio Henrique Ferreira Galvão |
| author_sort | Estela Regina Ramos Figueira |
| collection | DOAJ |
| description | Objective. The inhalation anesthetic sevoflurane has presented numerous biological activities, including anti-inflammatory properties and protective effects against tissue ischemic injury. This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postconditioning for short periods in the rescue of liver ischemia-reperfusion (IR) injury using a rat model. Materials and Methods. Twenty Wistar rats were divided into four groups: sham group, control ischemia group (partial warm liver ischemia for 45 min followed by 4 h of reperfusion), SPC group (administration of sevoflurane 2.5% for 15 min with 5 min of washout before liver IR), and SPPoC group (administration of sevoflurane 2.5% for 15 min before ischemia and 20 min during reperfusion). Results. All animals showed a decrease in the mean arterial pressure (MAP) and portal vein blood flow during ischemia. After 4 h of reperfusion, only the SPPoC group had MAP recovery. In both the SPC and SPPoC groups, there was a decrease in the ALT level and an increase in the bicarbonate and potassium serum levels. Only the SPPoC group showed an increase in the arterial blood ionized calcium level and a decrease in the IL-6 level after liver reperfusion. Therefore, this study demonstrated that sevoflurane preconditioning reduces hepatocellular injury and acid-base imbalance in liver ischemia. Furthermore, sevoflurane postconditioning promoted systemic hemodynamic recovery with a decrease in inflammatory response. |
| format | Article |
| id | doaj-art-2b75edcbec8348b3ba04a865bfd82aab |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-2b75edcbec8348b3ba04a865bfd82aab2025-02-03T06:01:26ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/57589845758984Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia ReperfusionEstela Regina Ramos Figueira0Joel Avancini Rocha-Filho1Cinthia Lanchotte2Ana Maria Mendonça Coelho3Mauro Nakatani4Eduardo Ryoiti Tatebe5Jonathan Augusto Venceslau Lima6Camilla Oliveira Mendes7Bruno Camargo Rocha Paim de Araujo8Emilio Elias Abdo9Luiz Carneiro D’Albuquerque10Flavio Henrique Ferreira Galvão11Department of Gastroenterology, Division of Digestive Surgery, Hospital das Clinicas of University of Sao Paulo School of Medicine, Sao Paulo, BrazilDepartment of Gastroenterology, Medical Investigation Laboratory LIM37, Hospital das Clinicas of University of Sao Paulo School of Medicine, Sao Paulo, BrazilDepartment of Gastroenterology, Medical Investigation Laboratory LIM37, Hospital das Clinicas of University of Sao Paulo School of Medicine, Sao Paulo, BrazilDepartment of Gastroenterology, Medical Investigation Laboratory LIM37, Hospital das Clinicas of University of Sao Paulo School of Medicine, Sao Paulo, BrazilDiscipline of Anesthesiology, Hospital das Clinicas of University of Sao Paulo School of Medicine, Sao Paulo, BrazilDepartment of Gastroenterology, Medical Investigation Laboratory LIM37, Hospital das Clinicas of University of Sao Paulo School of Medicine, Sao Paulo, BrazilMedical Student and Scientific Research Initiation in Medicine at University of Sao Paulo School of Medicine, BrazilDepartment of Gastroenterology, Medical Investigation Laboratory LIM37, Hospital das Clinicas of University of Sao Paulo School of Medicine, Sao Paulo, BrazilMedical Student and Scientific Research Initiation in Medicine at University of Sao Paulo School of Medicine, BrazilDepartment of Gastroenterology, Division of Digestive Surgery, Hospital das Clinicas of University of Sao Paulo School of Medicine, Sao Paulo, BrazilDepartment of Gastroenterology, Medical Investigation Laboratory LIM37, Hospital das Clinicas of University of Sao Paulo School of Medicine, Sao Paulo, BrazilDepartment of Gastroenterology, Medical Investigation Laboratory LIM37, Hospital das Clinicas of University of Sao Paulo School of Medicine, Sao Paulo, BrazilObjective. The inhalation anesthetic sevoflurane has presented numerous biological activities, including anti-inflammatory properties and protective effects against tissue ischemic injury. This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postconditioning for short periods in the rescue of liver ischemia-reperfusion (IR) injury using a rat model. Materials and Methods. Twenty Wistar rats were divided into four groups: sham group, control ischemia group (partial warm liver ischemia for 45 min followed by 4 h of reperfusion), SPC group (administration of sevoflurane 2.5% for 15 min with 5 min of washout before liver IR), and SPPoC group (administration of sevoflurane 2.5% for 15 min before ischemia and 20 min during reperfusion). Results. All animals showed a decrease in the mean arterial pressure (MAP) and portal vein blood flow during ischemia. After 4 h of reperfusion, only the SPPoC group had MAP recovery. In both the SPC and SPPoC groups, there was a decrease in the ALT level and an increase in the bicarbonate and potassium serum levels. Only the SPPoC group showed an increase in the arterial blood ionized calcium level and a decrease in the IL-6 level after liver reperfusion. Therefore, this study demonstrated that sevoflurane preconditioning reduces hepatocellular injury and acid-base imbalance in liver ischemia. Furthermore, sevoflurane postconditioning promoted systemic hemodynamic recovery with a decrease in inflammatory response.http://dx.doi.org/10.1155/2019/5758984 |
| spellingShingle | Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Cinthia Lanchotte Ana Maria Mendonça Coelho Mauro Nakatani Eduardo Ryoiti Tatebe Jonathan Augusto Venceslau Lima Camilla Oliveira Mendes Bruno Camargo Rocha Paim de Araujo Emilio Elias Abdo Luiz Carneiro D’Albuquerque Flavio Henrique Ferreira Galvão Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion Gastroenterology Research and Practice |
| title | Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion |
| title_full | Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion |
| title_fullStr | Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion |
| title_full_unstemmed | Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion |
| title_short | Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion |
| title_sort | sevoflurane preconditioning plus postconditioning decreases inflammatory response with hemodynamic recovery in experimental liver ischemia reperfusion |
| url | http://dx.doi.org/10.1155/2019/5758984 |
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