Virulence of fowl adenovirus (FAdV) serotype 4 strains impacts cell proliferation and immune response of primary chicken-embryo intestinal epithelial cells

Virulence of fowl adenovirus (FAdV) serotype 4 strains impacts cell proliferation and immune response of primary chicken-embryo intestinal epithelial cells

Abstract Fowl adenovirus serotype 4 (FAdV-4) causes hepatitis-hydropericardium syndrome (HHS) in chickens, leading to substantial economic losses. Following oral uptake, the virus infects intestinal epithelial cells (IEC) to overcome the first entrance barrier. The initial cellular interactions and...

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Main Authors: Katharina Kau-Strebinger, Ursula Reichart, Taniya Mitra, Beatrice Grafl, Michael Hess, Dieter Liebhart
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Veterinary Research
Subjects:
Intestinal epithelial cells (IEC)
fowl adenovirus serotype 4 (FAdV-4)
viral infection dynamics
immune response
Toll-like receptors (TLR)
cytokine expression
Online Access:https://doi.org/10.1186/s13567-025-01541-9
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https://doi.org/10.1186/s13567-025-01541-9

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