Comparison of Medical Treatments According to the Characteristics of Idiopathic Premature Ventricular Contractions: Beta-blockers or Calcium Channel Blockers?
Objective: Premature ventricular contractions (PVCs) are a common arrhythmic condition. The first approach in patients with symptomatic and frequent PVC is medical treatment, primarily beta-blockers (BB) or calcium channel blockers (CCB), but it is still unclear which of the two should be chosen. Th...
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Galenos Publishing House
2023-03-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-00532 |
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| author | Omer Faruk BAYCAN Serdar FIDAN Fatma Betul CELIK Mustafa Adem TATLISU Serhan OZYILDIRIM Mustafa CALISKAN |
| author_facet | Omer Faruk BAYCAN Serdar FIDAN Fatma Betul CELIK Mustafa Adem TATLISU Serhan OZYILDIRIM Mustafa CALISKAN |
| author_sort | Omer Faruk BAYCAN |
| collection | DOAJ |
| description | Objective: Premature ventricular contractions (PVCs) are a common arrhythmic condition. The first approach in patients with symptomatic and frequent PVC is medical treatment, primarily beta-blockers (BB) or calcium channel blockers (CCB), but it is still unclear which of the two should be chosen. This study investigated which drug treatment would be beneficial according to patient and electrocardiography (ECG) characteristics in patients with idiopathic PVC.
Methods: We retrospectively analyzed 156 patients with PVC who came to the cardiology outpatient clinic. Seventy-one patients were responsive to BB, and 85 were responsive to CCB. Their demographic and ECG characteristics were compared.
Results: The male ratio was higher (p<0.001), and the left ventricular ejection fraction was lower in BB responders than in CCB responders (p<0.001). Although the mean heart rate was higher in BB responders (p<0.001), the initial PVC burden was lower in BB responders than in CCB responders (p<0.001). The PVC QRS duration was longer in BB responders than in CCB responders (p<0.001). Similarly, the coupling interval variability was higher in BB responders (p=0.006).
Conclusions: The evaluation of clinical and ECG parameters in patients with frequent idiopathic PVCs may determine whether BBs or CCBs should be chosen as initial treatment. Further prospective studies are needed to verify our findings and establish their clinical applicability. |
| format | Article |
| id | doaj-art-2b6285b346714f46a50cfeb9b63a28c4 |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-2b6285b346714f46a50cfeb9b63a28c42025-01-30T07:05:46ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062023-03-01381323810.4274/MMJ.galenos.2023.00532MEDJ-00532Comparison of Medical Treatments According to the Characteristics of Idiopathic Premature Ventricular Contractions: Beta-blockers or Calcium Channel Blockers?Omer Faruk BAYCAN0Serdar FIDAN1Fatma Betul CELIK2Mustafa Adem TATLISU3Serhan OZYILDIRIM4Mustafa CALISKAN5Istanbul Medeniyet University Faculty of Medicine; Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Department of Cardiology, Istanbul, TurkeyKartal Kosuyolu Heart Training and Research Hospital, Clinic of Cardiology, Istanbul, TurkeyIstanbul Medeniyet University Faculty of Medicine; Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Department of Cardiology, Istanbul, TurkeyMedicana International Atasehir Hospital, Clinic of Cardiology, Istanbul, TurkeyIstanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine; Institute of Cardiology, Department of Cardiology, Istanbul, TurkeyIstanbul Medeniyet University Faculty of Medicine; Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Department of Cardiology, Istanbul, TurkeyObjective: Premature ventricular contractions (PVCs) are a common arrhythmic condition. The first approach in patients with symptomatic and frequent PVC is medical treatment, primarily beta-blockers (BB) or calcium channel blockers (CCB), but it is still unclear which of the two should be chosen. This study investigated which drug treatment would be beneficial according to patient and electrocardiography (ECG) characteristics in patients with idiopathic PVC. Methods: We retrospectively analyzed 156 patients with PVC who came to the cardiology outpatient clinic. Seventy-one patients were responsive to BB, and 85 were responsive to CCB. Their demographic and ECG characteristics were compared. Results: The male ratio was higher (p<0.001), and the left ventricular ejection fraction was lower in BB responders than in CCB responders (p<0.001). Although the mean heart rate was higher in BB responders (p<0.001), the initial PVC burden was lower in BB responders than in CCB responders (p<0.001). The PVC QRS duration was longer in BB responders than in CCB responders (p<0.001). Similarly, the coupling interval variability was higher in BB responders (p=0.006). Conclusions: The evaluation of clinical and ECG parameters in patients with frequent idiopathic PVCs may determine whether BBs or CCBs should be chosen as initial treatment. Further prospective studies are needed to verify our findings and establish their clinical applicability.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-00532premature ventricular contractionventricular arrhythmiab-blockercalcium channel blockerambulatory ecg monitoring |
| spellingShingle | Omer Faruk BAYCAN Serdar FIDAN Fatma Betul CELIK Mustafa Adem TATLISU Serhan OZYILDIRIM Mustafa CALISKAN Comparison of Medical Treatments According to the Characteristics of Idiopathic Premature Ventricular Contractions: Beta-blockers or Calcium Channel Blockers? Medeniyet Medical Journal premature ventricular contraction ventricular arrhythmia b-blocker calcium channel blocker ambulatory ecg monitoring |
| title | Comparison of Medical Treatments According to the Characteristics of Idiopathic Premature Ventricular Contractions: Beta-blockers or Calcium Channel Blockers? |
| title_full | Comparison of Medical Treatments According to the Characteristics of Idiopathic Premature Ventricular Contractions: Beta-blockers or Calcium Channel Blockers? |
| title_fullStr | Comparison of Medical Treatments According to the Characteristics of Idiopathic Premature Ventricular Contractions: Beta-blockers or Calcium Channel Blockers? |
| title_full_unstemmed | Comparison of Medical Treatments According to the Characteristics of Idiopathic Premature Ventricular Contractions: Beta-blockers or Calcium Channel Blockers? |
| title_short | Comparison of Medical Treatments According to the Characteristics of Idiopathic Premature Ventricular Contractions: Beta-blockers or Calcium Channel Blockers? |
| title_sort | comparison of medical treatments according to the characteristics of idiopathic premature ventricular contractions beta blockers or calcium channel blockers |
| topic | premature ventricular contraction ventricular arrhythmia b-blocker calcium channel blocker ambulatory ecg monitoring |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-00532 |
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