Herbicidal and Antibacterial Secondary Metabolites Isolated from the <i>Nicotiana tabacum</i>-Derived Endophytic Fungus <i>Aspergillus japonicus</i> TE-739D
Endophytic fungi possess a unique ability to produce abundant secondary metabolites, which play an active role in the growth and development of host plants. In this study, chemical investigations on the endophytic fungus <i>Aspergillus japonicus</i> TE-739D derived from the cultivated to...
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MDPI AG
2025-01-01
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| author | Haisu Wang Xiaolong Yuan Xinrong Huang Peng Zhang Gan Gu |
| author_facet | Haisu Wang Xiaolong Yuan Xinrong Huang Peng Zhang Gan Gu |
| author_sort | Haisu Wang |
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| description | Endophytic fungi possess a unique ability to produce abundant secondary metabolites, which play an active role in the growth and development of host plants. In this study, chemical investigations on the endophytic fungus <i>Aspergillus japonicus</i> TE-739D derived from the cultivated tobacco (<i>Nicotiana tabacum</i> L.) afforded two new polyketide derivatives, namely japoniones A (<b>1</b>) and B (<b>2</b>), as well as four previously reported compounds <b>3</b>–<b>6</b>. Their chemical structures were elucidated by detailed spectroscopic analyses and quantum chemical calculations. In the herbicidal assays on the germination and radicle growth of <i>Amaranthus retroflexus</i> L. and <i>Eleusine indica</i> seeds, compound <b>1</b> was found to inhibit the germ and radicle elongation. Notably, compound <b>2</b> showed potent herbicidal activity against <i>A. retroflexus</i> L. germ elongation, with an IC<sub>50</sub> value of 43.6 μg/mL, even higher than the positive control glyphosate (IC<sub>50</sub> = 76.0 μg/mL). Moreover, compound <b>4</b> demonstrated strong antibacterial effects against the pathogens <i>Bacillus cereus</i> and <i>Bacillus subtilis</i>, with a comparable MIC value of 16 μg/mL to the positive control chloramphenicol. These findings indicate that the endophytic fungus <i>A. japonicus</i> TE-739D holds significant metabolic potential to produce bioactive secondary metabolites, which are beneficial, providing survival value to the host plants. |
| format | Article |
| id | doaj-art-2b59d0dac0a2444cb478f31f4b49a65e |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| series | Plants |
| spelling | doaj-art-2b59d0dac0a2444cb478f31f4b49a65e2025-01-24T13:46:36ZengMDPI AGPlants2223-77472025-01-0114217310.3390/plants14020173Herbicidal and Antibacterial Secondary Metabolites Isolated from the <i>Nicotiana tabacum</i>-Derived Endophytic Fungus <i>Aspergillus japonicus</i> TE-739DHaisu Wang0Xiaolong Yuan1Xinrong Huang2Peng Zhang3Gan Gu4Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, ChinaTobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, ChinaTobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, ChinaTobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, ChinaTobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, ChinaEndophytic fungi possess a unique ability to produce abundant secondary metabolites, which play an active role in the growth and development of host plants. In this study, chemical investigations on the endophytic fungus <i>Aspergillus japonicus</i> TE-739D derived from the cultivated tobacco (<i>Nicotiana tabacum</i> L.) afforded two new polyketide derivatives, namely japoniones A (<b>1</b>) and B (<b>2</b>), as well as four previously reported compounds <b>3</b>–<b>6</b>. Their chemical structures were elucidated by detailed spectroscopic analyses and quantum chemical calculations. In the herbicidal assays on the germination and radicle growth of <i>Amaranthus retroflexus</i> L. and <i>Eleusine indica</i> seeds, compound <b>1</b> was found to inhibit the germ and radicle elongation. Notably, compound <b>2</b> showed potent herbicidal activity against <i>A. retroflexus</i> L. germ elongation, with an IC<sub>50</sub> value of 43.6 μg/mL, even higher than the positive control glyphosate (IC<sub>50</sub> = 76.0 μg/mL). Moreover, compound <b>4</b> demonstrated strong antibacterial effects against the pathogens <i>Bacillus cereus</i> and <i>Bacillus subtilis</i>, with a comparable MIC value of 16 μg/mL to the positive control chloramphenicol. These findings indicate that the endophytic fungus <i>A. japonicus</i> TE-739D holds significant metabolic potential to produce bioactive secondary metabolites, which are beneficial, providing survival value to the host plants.https://www.mdpi.com/2223-7747/14/2/173endophytic fungus<i>Aspergillus japonicus</i>secondary metabolitespolyketidesherbicidal activityantibacterial activity |
| spellingShingle | Haisu Wang Xiaolong Yuan Xinrong Huang Peng Zhang Gan Gu Herbicidal and Antibacterial Secondary Metabolites Isolated from the <i>Nicotiana tabacum</i>-Derived Endophytic Fungus <i>Aspergillus japonicus</i> TE-739D Plants endophytic fungus <i>Aspergillus japonicus</i> secondary metabolites polyketides herbicidal activity antibacterial activity |
| title | Herbicidal and Antibacterial Secondary Metabolites Isolated from the <i>Nicotiana tabacum</i>-Derived Endophytic Fungus <i>Aspergillus japonicus</i> TE-739D |
| title_full | Herbicidal and Antibacterial Secondary Metabolites Isolated from the <i>Nicotiana tabacum</i>-Derived Endophytic Fungus <i>Aspergillus japonicus</i> TE-739D |
| title_fullStr | Herbicidal and Antibacterial Secondary Metabolites Isolated from the <i>Nicotiana tabacum</i>-Derived Endophytic Fungus <i>Aspergillus japonicus</i> TE-739D |
| title_full_unstemmed | Herbicidal and Antibacterial Secondary Metabolites Isolated from the <i>Nicotiana tabacum</i>-Derived Endophytic Fungus <i>Aspergillus japonicus</i> TE-739D |
| title_short | Herbicidal and Antibacterial Secondary Metabolites Isolated from the <i>Nicotiana tabacum</i>-Derived Endophytic Fungus <i>Aspergillus japonicus</i> TE-739D |
| title_sort | herbicidal and antibacterial secondary metabolites isolated from the i nicotiana tabacum i derived endophytic fungus i aspergillus japonicus i te 739d |
| topic | endophytic fungus <i>Aspergillus japonicus</i> secondary metabolites polyketides herbicidal activity antibacterial activity |
| url | https://www.mdpi.com/2223-7747/14/2/173 |
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