Temporomandibular Disorders Related to Stress and HPA-Axis Regulation
Temporomandibular disorders (TMDs) are characterized by pain and dysfunction in the masticatory apparatus and the temporomandibular joint (TMJ). Previous trauma, stress symptoms, psychosocial impairment, and catastrophizing have been related to TMD. To assess if the hypothalamic-pituitary-adrenal (H...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2018/7020751 |
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| _version_ | 1832545423040970752 |
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| author | Kordian Staniszewski Henning Lygre Ersilia Bifulco Siv Kvinnsland Lisa Willassen Espen Helgeland Trond Berge Annika Rosén |
| author_facet | Kordian Staniszewski Henning Lygre Ersilia Bifulco Siv Kvinnsland Lisa Willassen Espen Helgeland Trond Berge Annika Rosén |
| author_sort | Kordian Staniszewski |
| collection | DOAJ |
| description | Temporomandibular disorders (TMDs) are characterized by pain and dysfunction in the masticatory apparatus and the temporomandibular joint (TMJ). Previous trauma, stress symptoms, psychosocial impairment, and catastrophizing have been related to TMD. To assess if the hypothalamic-pituitary-adrenal (HPA) axis is upregulated in TMD patients, we performed a cross-sectional study with saliva from 44 TMD patients and 44 healthy sex- and age-matched controls for cortisol (F) and cortisone (E) with liquid chromatography-tandem mass spectrometry. Furthermore, we calculated the F/E ratio for the evaluation of 11β-hydroxysteroid dehydrogenase activity. We also assessed anxiety/depression and pain catastrophizing scores from a questionnaire that participants completed prior to the examination. We found that F (P=0.01), E (P=0.04), the F/E ratio (P=0.002), and the sum of glucocorticoids (E + E) in saliva (P=0.02) were significantly higher in the TMD group. Anxiety/depression and catastrophizing scores were also significantly higher in the TMD group (P<0.0001). Our findings indicate that patients with TMDs may have an upregulated HPA axis with higher F secretion from the adrenal cortex. Anxiety/depression and pain catastrophizing scores were significantly higher in the TMD group, and psychological factors may contribute to chronic upregulation of the HPA axis. |
| format | Article |
| id | doaj-art-2b3a0a9dcddc414085482b4a3de3ca1b |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-2b3a0a9dcddc414085482b4a3de3ca1b2025-02-03T07:25:46ZengWileyPain Research and Management1203-67651918-15232018-01-01201810.1155/2018/70207517020751Temporomandibular Disorders Related to Stress and HPA-Axis RegulationKordian Staniszewski0Henning Lygre1Ersilia Bifulco2Siv Kvinnsland3Lisa Willassen4Espen Helgeland5Trond Berge6Annika Rosén7Department of Clinical Dentistry, University of Bergen, Bergen, NorwayDepartment of Clinical Dentistry, University of Bergen, Bergen, NorwayDepartment of Clinical Science, University of Bergen, Bergen, NorwayDepartment of Clinical Dentistry, University of Bergen, Bergen, NorwayDepartment of Clinical Dentistry, University of Bergen, Bergen, NorwayDepartment of Clinical Dentistry, University of Bergen, Bergen, NorwayDepartment of Clinical Dentistry, University of Bergen, Bergen, NorwayDepartment of Clinical Dentistry, University of Bergen, Bergen, NorwayTemporomandibular disorders (TMDs) are characterized by pain and dysfunction in the masticatory apparatus and the temporomandibular joint (TMJ). Previous trauma, stress symptoms, psychosocial impairment, and catastrophizing have been related to TMD. To assess if the hypothalamic-pituitary-adrenal (HPA) axis is upregulated in TMD patients, we performed a cross-sectional study with saliva from 44 TMD patients and 44 healthy sex- and age-matched controls for cortisol (F) and cortisone (E) with liquid chromatography-tandem mass spectrometry. Furthermore, we calculated the F/E ratio for the evaluation of 11β-hydroxysteroid dehydrogenase activity. We also assessed anxiety/depression and pain catastrophizing scores from a questionnaire that participants completed prior to the examination. We found that F (P=0.01), E (P=0.04), the F/E ratio (P=0.002), and the sum of glucocorticoids (E + E) in saliva (P=0.02) were significantly higher in the TMD group. Anxiety/depression and catastrophizing scores were also significantly higher in the TMD group (P<0.0001). Our findings indicate that patients with TMDs may have an upregulated HPA axis with higher F secretion from the adrenal cortex. Anxiety/depression and pain catastrophizing scores were significantly higher in the TMD group, and psychological factors may contribute to chronic upregulation of the HPA axis.http://dx.doi.org/10.1155/2018/7020751 |
| spellingShingle | Kordian Staniszewski Henning Lygre Ersilia Bifulco Siv Kvinnsland Lisa Willassen Espen Helgeland Trond Berge Annika Rosén Temporomandibular Disorders Related to Stress and HPA-Axis Regulation Pain Research and Management |
| title | Temporomandibular Disorders Related to Stress and HPA-Axis Regulation |
| title_full | Temporomandibular Disorders Related to Stress and HPA-Axis Regulation |
| title_fullStr | Temporomandibular Disorders Related to Stress and HPA-Axis Regulation |
| title_full_unstemmed | Temporomandibular Disorders Related to Stress and HPA-Axis Regulation |
| title_short | Temporomandibular Disorders Related to Stress and HPA-Axis Regulation |
| title_sort | temporomandibular disorders related to stress and hpa axis regulation |
| url | http://dx.doi.org/10.1155/2018/7020751 |
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