Mediators of Inflammation in Topical Therapy of Skin Cancers
Taking into consideration that the immune system plays a very important role in the development of melanoma and non-melanoma skin cancers, which have a high prevalence in immunosuppressed patients and after prolonged ultraviolet radiation, the interest in developing novel therapies, in particular ta...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/8369690 |
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| _version_ | 1832564047805939712 |
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| author | Vlad Mihai Voiculescu Cristina Victoria Lisievici Mihai Lupu Cristina Vajaitu Carmen Cristina Draghici Alexandra Victoria Popa Iulia Solomon Teona Ioana Sebe Maria Magdalena Constantin Constantin Caruntu |
| author_facet | Vlad Mihai Voiculescu Cristina Victoria Lisievici Mihai Lupu Cristina Vajaitu Carmen Cristina Draghici Alexandra Victoria Popa Iulia Solomon Teona Ioana Sebe Maria Magdalena Constantin Constantin Caruntu |
| author_sort | Vlad Mihai Voiculescu |
| collection | DOAJ |
| description | Taking into consideration that the immune system plays a very important role in the development of melanoma and non-melanoma skin cancers, which have a high prevalence in immunosuppressed patients and after prolonged ultraviolet radiation, the interest in developing novel therapies, in particular targeting the inflammation in cancer, has increased in the past years. The latest data suggest that therapies such as imiquimod (IMQ), ingenol mebutate (IM), 5-fluorouracil (5-FU), retinoids, and nonsteroidal anti-inflammatory drugs (NSAIDs) have been used with success in the topical treatment of some cancers. Herein, we review the topical treatment targeting the inflammation in skin cancer and the mechanisms involved in these processes. Currently, various associations have shown a superior success rate than monotherapy, such as systemic acitretin and topical IMQ, topical 5-FU with tretinoin cream, or IMQ with checkpoint inhibitor cytotoxic T lymphocyte antigen 4. Novel therapies targeting Toll-like receptor-7 (TLR-7) with higher selectivity than IMQ are also of great interest. |
| format | Article |
| id | doaj-art-2b1c251fca034370b8673e7e8a2cc9dd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2b1c251fca034370b8673e7e8a2cc9dd2025-02-03T01:11:58ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/83696908369690Mediators of Inflammation in Topical Therapy of Skin CancersVlad Mihai Voiculescu0Cristina Victoria Lisievici1Mihai Lupu2Cristina Vajaitu3Carmen Cristina Draghici4Alexandra Victoria Popa5Iulia Solomon6Teona Ioana Sebe7Maria Magdalena Constantin8Constantin Caruntu9Department of Dermatology, “ELIAS” University Emergency Hospital, Bucharest, RomaniaDepartment of Dermatology, “ELIAS” University Emergency Hospital, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy Bucharest, Romania, Bucharest, RomaniaDepartment of Dermatology, “ELIAS” University Emergency Hospital, Bucharest, RomaniaDepartment of Dermatology, “ELIAS” University Emergency Hospital, Bucharest, RomaniaDepartment of Dermatology, “ELIAS” University Emergency Hospital, Bucharest, RomaniaDepartment of Dermatology, “ELIAS” University Emergency Hospital, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy Bucharest, Romania, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy Bucharest, Romania, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy Bucharest, Romania, Bucharest, RomaniaTaking into consideration that the immune system plays a very important role in the development of melanoma and non-melanoma skin cancers, which have a high prevalence in immunosuppressed patients and after prolonged ultraviolet radiation, the interest in developing novel therapies, in particular targeting the inflammation in cancer, has increased in the past years. The latest data suggest that therapies such as imiquimod (IMQ), ingenol mebutate (IM), 5-fluorouracil (5-FU), retinoids, and nonsteroidal anti-inflammatory drugs (NSAIDs) have been used with success in the topical treatment of some cancers. Herein, we review the topical treatment targeting the inflammation in skin cancer and the mechanisms involved in these processes. Currently, various associations have shown a superior success rate than monotherapy, such as systemic acitretin and topical IMQ, topical 5-FU with tretinoin cream, or IMQ with checkpoint inhibitor cytotoxic T lymphocyte antigen 4. Novel therapies targeting Toll-like receptor-7 (TLR-7) with higher selectivity than IMQ are also of great interest.http://dx.doi.org/10.1155/2019/8369690 |
| spellingShingle | Vlad Mihai Voiculescu Cristina Victoria Lisievici Mihai Lupu Cristina Vajaitu Carmen Cristina Draghici Alexandra Victoria Popa Iulia Solomon Teona Ioana Sebe Maria Magdalena Constantin Constantin Caruntu Mediators of Inflammation in Topical Therapy of Skin Cancers Mediators of Inflammation |
| title | Mediators of Inflammation in Topical Therapy of Skin Cancers |
| title_full | Mediators of Inflammation in Topical Therapy of Skin Cancers |
| title_fullStr | Mediators of Inflammation in Topical Therapy of Skin Cancers |
| title_full_unstemmed | Mediators of Inflammation in Topical Therapy of Skin Cancers |
| title_short | Mediators of Inflammation in Topical Therapy of Skin Cancers |
| title_sort | mediators of inflammation in topical therapy of skin cancers |
| url | http://dx.doi.org/10.1155/2019/8369690 |
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