Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis

Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis

Background: An immunosuppressive tumor microenvironment limits the efficacy of immunotherapy, thus patients with MSS and pMMR mCRC often face great challenges. Methods: In this phase II trial, patients received Gamma Knife SBRT combined with Tislelizumab. Biomarker analysis was performed pre- and po...

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Main Authors: Yiran Zhang, Hanyang Guan, Shijin Liu, Haoquan Li, Zili Bian, Jiashuai He, Zhan Zhao, Shenghui Qiu, Tianmu Mo, Xiangwei Zhang, Zuyang Chen, Hui Ding, Xiaoxu Zhao, Liang Wang, Yunlong Pan, Jinghua Pan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
stereotactic body radiation therapy
mismatch repair-proficient
tislelizumab
metastatic colorectal cancer
immune checkpoint inhibitors
PD-L1
Online Access:https://elifesciences.org/articles/103559
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https://elifesciences.org/articles/103559

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