Roseoside Is a Bioactive Compound in <i>Kirengeshoma koreana</i> Nakai Extract with Potent In Vitro Antiviral Activity Against Hepatitis C Virus
Hepatitis C virus (HCV) is a pathogen that causes cirrhosis and hepatocellular carcinoma through chronic hepatitis C. This study focused on the anti-HCV activity of a 70% ethanol extract of <i>Kirengeshoma koreana</i> Nakai (KKE) and its bioactive chemical constituent(s). The KKE and its...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/29/21/5130 |
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| Summary: | Hepatitis C virus (HCV) is a pathogen that causes cirrhosis and hepatocellular carcinoma through chronic hepatitis C. This study focused on the anti-HCV activity of a 70% ethanol extract of <i>Kirengeshoma koreana</i> Nakai (KKE) and its bioactive chemical constituent(s). The KKE and its <i>n</i>-butanol (<i>n</i>-BuOH) fraction induced a significant reduction in HCV RNA levels without inducing cytotoxicity. A high-performance liquid chromatography–mass spectrometry (HPLC-MS) analysis revealed the presence of roseoside in the <i>n</i>-butanol fraction of the KKE, which inhibited HCV RNA replication in a concentration- and time-dependent manner without exerting cytotoxicity. Consistent with in silico molecular docking analysis data, roseoside targets and inhibits HCV NS5A/B replicase. Collectively, our findings demonstrate that roseoside is a chemical constituent in KKE that interferes with HCV replication by targeting NS5A/B replicase. |
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| ISSN: | 1420-3049 |