Multi-tissue transcriptome-wide association study identifies novel candidate genes and pleiotropy effects across four abdominal hernia subtypes

Multi-tissue transcriptome-wide association study identifies novel candidate genes and pleiotropy effects across four abdominal hernia subtypes

Summary: Abdominal hernias are caused by the protrusion of an organ or tissue through a weakened abdominal wall. Genome-wide association studies (GWASs) have identified 81 genetic susceptibility loci for different hernia subtypes, with 26 loci associated with more than one hernia type; however, addi...

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Main Authors: Dima L. Chaar, Chen Jiang, Brandon Cowan, Sahil Patel, Mark Kvale, Jie Yin, Rouzbeh Mostaedi, Nadav Ahituv, Eric Jorgenson, Thomas J. Hoffmann, Hélène Choquet
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:HGG Advances
Subjects:
genetics
transcriptome-wide association study
genome-wide association study
multi-tissue
abdominal hernia
inguinal hernia
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247725000399
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http://www.sciencedirect.com/science/article/pii/S2666247725000399

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