Assessment of Opuntia ficus-indica supplementation on enhancing antioxidant levels
Abstract Opuntia ficus-indica (OFi) is a major fruit source prevalent in semiarid and arid regions across various countries worldwide. It is widely recognised for its potential health benefits; however, most studies investigating its effects have been limited to pre-clinical models, highlighting the...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87680-7 |
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| author | Rahela Zaman Eugenie Sin Sing Tan Normina Ahmad Bustami Farahnaz Amini Marjan Sadat Seghayat Yu Bin Ho Chung Keat Tan |
| author_facet | Rahela Zaman Eugenie Sin Sing Tan Normina Ahmad Bustami Farahnaz Amini Marjan Sadat Seghayat Yu Bin Ho Chung Keat Tan |
| author_sort | Rahela Zaman |
| collection | DOAJ |
| description | Abstract Opuntia ficus-indica (OFi) is a major fruit source prevalent in semiarid and arid regions across various countries worldwide. It is widely recognised for its potential health benefits; however, most studies investigating its effects have been limited to pre-clinical models, highlighting the need for further validation through clinical trials. This study aimed to evaluate the effectiveness of OFi supplementation in enhancing antioxidant levels. Fifty healthy participants, aged 18 years and older, including males and females, received a daily OFi supplement of 1500 mg for 3 months. These findings revealed a significant 48.1% increase in salivary total antioxidant capacity (TAC) (P < 0.001), indicating improved antioxidant activity. Simultaneously, oxidative stress biomarkers showed substantial reductions: malondialdehyde (MDA) decreased by 28.3%, nitrotyrosine (3-NT) decreased by 51.5%, and 8-hydroxy-2’-deoxyguanosine (8-OHdG) decreased by 59.8% (P < 0.001). Furthermore, participants reported a 20.1% improvement (P < 0.001) in Visual Analogue Scales (VAS), reflecting a notable enhancement in overall well-being. In conclusion, OFi exhibited promising efficacy in elevating antioxidant levels and mitigating oxidative stress. These findings suggest its potential as an adjuvant therapy for managing chronic conditions associated with oxidative stress. |
| format | Article |
| id | doaj-art-2a7267f055dc4de8b5a775e02ce2fe76 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-2a7267f055dc4de8b5a775e02ce2fe762025-02-02T12:17:48ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-87680-7Assessment of Opuntia ficus-indica supplementation on enhancing antioxidant levelsRahela Zaman0Eugenie Sin Sing Tan1Normina Ahmad Bustami2Farahnaz Amini3Marjan Sadat Seghayat4Yu Bin Ho5Chung Keat Tan6School of Healthy Aging, Aesthetic and Regenerative Medicine, Faculty of Medicine and Health Sciences, UCSI UniversitySchool of Healthy Aging, Aesthetic and Regenerative Medicine, Faculty of Medicine and Health Sciences, UCSI UniversitySchool of Healthy Aging, Aesthetic and Regenerative Medicine, Faculty of Medicine and Health Sciences, UCSI UniversitySchool of Healthy Aging, Aesthetic and Regenerative Medicine, Faculty of Medicine and Health Sciences, UCSI UniversityIkigai Medical Centre, Dubai MallFaculty of Medicine and Health Sciences, University Putra MalaysiaSchool of Healthy Aging, Aesthetic and Regenerative Medicine, Faculty of Medicine and Health Sciences, UCSI UniversityAbstract Opuntia ficus-indica (OFi) is a major fruit source prevalent in semiarid and arid regions across various countries worldwide. It is widely recognised for its potential health benefits; however, most studies investigating its effects have been limited to pre-clinical models, highlighting the need for further validation through clinical trials. This study aimed to evaluate the effectiveness of OFi supplementation in enhancing antioxidant levels. Fifty healthy participants, aged 18 years and older, including males and females, received a daily OFi supplement of 1500 mg for 3 months. These findings revealed a significant 48.1% increase in salivary total antioxidant capacity (TAC) (P < 0.001), indicating improved antioxidant activity. Simultaneously, oxidative stress biomarkers showed substantial reductions: malondialdehyde (MDA) decreased by 28.3%, nitrotyrosine (3-NT) decreased by 51.5%, and 8-hydroxy-2’-deoxyguanosine (8-OHdG) decreased by 59.8% (P < 0.001). Furthermore, participants reported a 20.1% improvement (P < 0.001) in Visual Analogue Scales (VAS), reflecting a notable enhancement in overall well-being. In conclusion, OFi exhibited promising efficacy in elevating antioxidant levels and mitigating oxidative stress. These findings suggest its potential as an adjuvant therapy for managing chronic conditions associated with oxidative stress.https://doi.org/10.1038/s41598-025-87680-7Opuntia ficus-indicaSupplementAntioxidantReactive oxygen species (ROS)Clinical trial |
| spellingShingle | Rahela Zaman Eugenie Sin Sing Tan Normina Ahmad Bustami Farahnaz Amini Marjan Sadat Seghayat Yu Bin Ho Chung Keat Tan Assessment of Opuntia ficus-indica supplementation on enhancing antioxidant levels Scientific Reports Opuntia ficus-indica Supplement Antioxidant Reactive oxygen species (ROS) Clinical trial |
| title | Assessment of Opuntia ficus-indica supplementation on enhancing antioxidant levels |
| title_full | Assessment of Opuntia ficus-indica supplementation on enhancing antioxidant levels |
| title_fullStr | Assessment of Opuntia ficus-indica supplementation on enhancing antioxidant levels |
| title_full_unstemmed | Assessment of Opuntia ficus-indica supplementation on enhancing antioxidant levels |
| title_short | Assessment of Opuntia ficus-indica supplementation on enhancing antioxidant levels |
| title_sort | assessment of opuntia ficus indica supplementation on enhancing antioxidant levels |
| topic | Opuntia ficus-indica Supplement Antioxidant Reactive oxygen species (ROS) Clinical trial |
| url | https://doi.org/10.1038/s41598-025-87680-7 |
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