Efficacy and Safety of a Diet Enriched with EPA and DHA, Turmeric Extract and Hydrolysed Collagen in Management of Naturally Occurring Osteoarthritis in Cats: A Prospective, Randomised, Blinded, Placebo- and Time-Controlled Study

Efficacy and Safety of a Diet Enriched with EPA and DHA, Turmeric Extract and Hydrolysed Collagen in Management of Naturally Occurring Osteoarthritis in Cats: A Prospective, Randomised, Blinded, Placebo- and Time-Controlled Study

This study evaluated a therapeutic diet high in eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) of marine source (EPA:DHA ratio 0.69:1), turmeric extract, and hydrolysed collagen in cats (<i>N</i> = 30) with naturally occurring osteoarthritis (OA) over a 13-week (W) period, followe...

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Main Authors: Manuela Lefort-Holguin, Aliénor Delsart, Colombe Otis, Maxim Moreau, Maude Barbeau-Grégoire, Florence Mellet, Vincent Biourge, Bertrand Lussier, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Eric Troncy
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Animals
Subjects:
omega-3
curcuminoid
feline
chronic pain
biomechanical
functional alterations
Online Access:https://www.mdpi.com/2076-2615/14/22/3298
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Summary:This study evaluated a therapeutic diet high in eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) of marine source (EPA:DHA ratio 0.69:1), turmeric extract, and hydrolysed collagen in cats (<i>N</i> = 30) with naturally occurring osteoarthritis (OA) over a 13-week (W) period, followed by a 4-W washout, using four previously validated pain/functional outcomes. Compared to the placebo diet, the therapeutic diet significantly improved peak vertical force (<i>p</i> = 0.017; W16, 64% responders), correlating to enhanced weight bearing; stair assay compliance (<i>p</i> < 0.001; W16, 87% responders), reflecting reduced fatigue related to OA pain; night-time actimetry (cohort effect; <i>p</i> = 0.05, 67% responders), suggesting greater spontaneous mobility and comfort; and MI-CAT(V) score (cohort effect; <i>p</i> < 0.001, 80% responders), indicating reduced functional impairments. The earliest therapeutic response was observed at W06, marked by an inflection point between actimetric linear regressions of both cohorts, confirmed by significant MI-CAT(V) differences (<i>p</i> < 0.007; W08; W12; W16). The MI-CAT(V) clinical metrology instrument was validated for inter-rater reliability, minimal placebo effect (<15% responders), and OA severity clustering. Despite baseline differences in biomechanical assessments (<i>p</i> < 0.05), both moderate and severe OA clusters responded equally positively to the therapeutic diet. Based on all outcomes, the therapeutic diet showed promise for the long-term management of feline OA, with no observed side effects.
ISSN:2076-2615

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