Quantification of signal amplification for receptors: the Kd/EC50 ratio of full agonists as a gain parameter
Concentration-response relationships connecting the concentration of ligands to the responses they produce are central to pharmacology in general and form the core of quantitative pharmacology. While typically they can be well-described by hyperbolic functions (sigmoid on commonly used semi-log scal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1541872/full |
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