The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System?
It is well known that the brain renin-angiotensin (RAS) system plays an essential role in the development of hypertension, mainly through the modulation of autonomic activities and vasopressin release. However, how the brain synthesizes angiotensin (Ang) II has been a debate for decades, largely due...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/290635 |
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| author | Wencheng Li Hua Peng Dale M. Seth Yumei Feng |
| author_facet | Wencheng Li Hua Peng Dale M. Seth Yumei Feng |
| author_sort | Wencheng Li |
| collection | DOAJ |
| description | It is well known that the brain renin-angiotensin (RAS) system plays an essential role in the development of hypertension, mainly through the modulation of autonomic activities and vasopressin release. However, how the brain synthesizes angiotensin (Ang) II has been a debate for decades, largely due to the low renin activity. This paper first describes the expression of the vasoconstrictive arm of RAS components in the brain as well as their physiological and pathophysiological significance. It then focus on the (pro)renin receptor (PRR), a newly discovered component of the RAS which has a high level in the brain. We review the role of prorenin and PRR in peripheral organs and emphasize the involvement of brain PRR in the pathogenesis of hypertension. Some future perspectives in PRR research are heighted with respect to novel therapeutic target for the treatment of hypertension and other cardiovascular diseases. |
| format | Article |
| id | doaj-art-2a0c3d8bcde246a4b56f60eae3586609 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-2a0c3d8bcde246a4b56f60eae35866092025-02-03T05:57:07ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/290635290635The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System?Wencheng Li0Hua Peng1Dale M. Seth2Yumei Feng3Department of Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, 1430 Tulane Avenue SL-39, New Orleans, LA 70112, USADepartment of Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, 1430 Tulane Avenue SL-39, New Orleans, LA 70112, USADepartment of Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, 1430 Tulane Avenue SL-39, New Orleans, LA 70112, USADepartment of Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, 1430 Tulane Avenue SL-39, New Orleans, LA 70112, USAIt is well known that the brain renin-angiotensin (RAS) system plays an essential role in the development of hypertension, mainly through the modulation of autonomic activities and vasopressin release. However, how the brain synthesizes angiotensin (Ang) II has been a debate for decades, largely due to the low renin activity. This paper first describes the expression of the vasoconstrictive arm of RAS components in the brain as well as their physiological and pathophysiological significance. It then focus on the (pro)renin receptor (PRR), a newly discovered component of the RAS which has a high level in the brain. We review the role of prorenin and PRR in peripheral organs and emphasize the involvement of brain PRR in the pathogenesis of hypertension. Some future perspectives in PRR research are heighted with respect to novel therapeutic target for the treatment of hypertension and other cardiovascular diseases.http://dx.doi.org/10.1155/2012/290635 |
| spellingShingle | Wencheng Li Hua Peng Dale M. Seth Yumei Feng The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System? International Journal of Hypertension |
| title | The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System? |
| title_full | The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System? |
| title_fullStr | The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System? |
| title_full_unstemmed | The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System? |
| title_short | The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System? |
| title_sort | prorenin and pro renin receptor new players in the brain renin angiotensin system |
| url | http://dx.doi.org/10.1155/2012/290635 |
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