Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems

Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems

Abstract Cancer remains the second leading cause of death globally, driving the need for innovative therapies. Among natural compounds, maytansinoids have shown significant promise, contributing to nearly 25% of recently approved anticancer drugs. Despite their potential, early clinical trials faced...

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Main Authors: Matteo Perra, Ines Castangia, Matteo Aroffu, Federica Fulgheri, Rita Abi-Rached, Maria Letizia Manca, Hernán Cortés, María Luisa Del Prado-Audelo, Carla Nomura-Contreras, Alejandra Romero-Montero, Dietrich Büsselberg, Gerardo Leyva-Gómez, Javad Sharifi-Rad, Daniela Calina
Format: Article
Language:English
Published: Springer 2025-01-01
Series:Discover Oncology
Subjects:
Maytansine
Maytansinoid-based therapies
Antibody-maytansinoid conjugates
Natural compounds
Anticancer studies
Microtubules polymerization inhibitors
Online Access:https://doi.org/10.1007/s12672-025-01820-z
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https://doi.org/10.1007/s12672-025-01820-z

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