Micronized purified flavonoid fraction (daflon) improves sexual function by modulating NF-kB /NO/cGMP and steroidogenic signaling in cisplatin-treated male Wistar rats

Micronized purified flavonoid fraction (daflon) improves sexual function by modulating NF-kB /NO/cGMP and steroidogenic signaling in cisplatin-treated male Wistar rats

Cisplatin is known to induce sexual dysfunction by suppressing testosterone levels. It also upregulates nuclear factor-kappa B (NF-kB), which mediates nitric oxide (NO)-dependent endothelial dysfunction. This study evaluated the effects of daflon, a micronized purified flavonoid fraction that contai...

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Bibliographic Details
Main Authors: Akhigbe RE, Akhigbe TM, Adegbola CA
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Chemotherapy
Cisplatin
Daflon
Male infertility
NO/cGMP
Sexual dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825002316
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http://www.sciencedirect.com/science/article/pii/S2405580825002316

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