Saliva: Physiology and Diagnostic Potential in Health and Disease
Saliva has been described as the mirror of the body. In a world of soaring healthcare costs and an environment where rapid diagnosis may be critical to a positive patient outcome, saliva is emerging as a viable alternative to blood sampling. In this review, we discuss the composition and various phy...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.38 |
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| _version_ | 1832558574128070656 |
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| author | Sebastien J. C. Farnaud Ourania Kosti Stephen J. Getting Derek Renshaw |
| author_facet | Sebastien J. C. Farnaud Ourania Kosti Stephen J. Getting Derek Renshaw |
| author_sort | Sebastien J. C. Farnaud |
| collection | DOAJ |
| description | Saliva has been described as the mirror of the body. In a world of soaring healthcare costs and an environment where rapid diagnosis may be critical to a positive patient outcome, saliva is emerging as a viable alternative to blood sampling. In this review, we discuss the composition and various physiological roles of saliva in the oral cavity, including soft tissue protection, antimicrobial activities, and oral tissue repair. We then explore saliva as a diagnostic marker of local oral disease and focus particularly on oral cancers. The cancer theme continues when we focus on systemic disease diagnosis from salivary biomarkers. Communicable disease is the focus of the next section where we review the literature relating to the direct and indirect detection of pathogenic infections from human saliva. Finally, we discuss hormones involved in appetite regulation and whether saliva is a viable alternative to blood in order to monitor hormones that are involved in satiety. |
| format | Article |
| id | doaj-art-29d79a0f717c4e5e9ad2acfa48b91ea5 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-29d79a0f717c4e5e9ad2acfa48b91ea52025-02-03T01:32:01ZengWileyThe Scientific World Journal1537-744X2010-01-011043445610.1100/tsw.2010.38Saliva: Physiology and Diagnostic Potential in Health and DiseaseSebastien J. C. Farnaud0Ourania Kosti1Stephen J. Getting2Derek Renshaw3Inflammation and Infection Group, School of Life Sciences, University of Westminster, London, UKDivision of Carcinogenesis, Biomarkers and Epidemiology Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USAInflammation and Infection Group, School of Life Sciences, University of Westminster, London, UKInflammation and Infection Group, School of Life Sciences, University of Westminster, London, UKSaliva has been described as the mirror of the body. In a world of soaring healthcare costs and an environment where rapid diagnosis may be critical to a positive patient outcome, saliva is emerging as a viable alternative to blood sampling. In this review, we discuss the composition and various physiological roles of saliva in the oral cavity, including soft tissue protection, antimicrobial activities, and oral tissue repair. We then explore saliva as a diagnostic marker of local oral disease and focus particularly on oral cancers. The cancer theme continues when we focus on systemic disease diagnosis from salivary biomarkers. Communicable disease is the focus of the next section where we review the literature relating to the direct and indirect detection of pathogenic infections from human saliva. Finally, we discuss hormones involved in appetite regulation and whether saliva is a viable alternative to blood in order to monitor hormones that are involved in satiety.http://dx.doi.org/10.1100/tsw.2010.38 |
| spellingShingle | Sebastien J. C. Farnaud Ourania Kosti Stephen J. Getting Derek Renshaw Saliva: Physiology and Diagnostic Potential in Health and Disease The Scientific World Journal |
| title | Saliva: Physiology and Diagnostic Potential in Health and Disease |
| title_full | Saliva: Physiology and Diagnostic Potential in Health and Disease |
| title_fullStr | Saliva: Physiology and Diagnostic Potential in Health and Disease |
| title_full_unstemmed | Saliva: Physiology and Diagnostic Potential in Health and Disease |
| title_short | Saliva: Physiology and Diagnostic Potential in Health and Disease |
| title_sort | saliva physiology and diagnostic potential in health and disease |
| url | http://dx.doi.org/10.1100/tsw.2010.38 |
| work_keys_str_mv | AT sebastienjcfarnaud salivaphysiologyanddiagnosticpotentialinhealthanddisease AT ouraniakosti salivaphysiologyanddiagnosticpotentialinhealthanddisease AT stephenjgetting salivaphysiologyanddiagnosticpotentialinhealthanddisease AT derekrenshaw salivaphysiologyanddiagnosticpotentialinhealthanddisease |