Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis

Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis

ABSTRACT Pleural infections are common and associated with substantial healthcare costs, morbidity, and mortality. Accurate diagnosis remains challenging due to low culture positivity rates, frequent polymicrobial involvement, and non-specific diagnostic biomarkers. Here, we undertook a prospective...

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Main Authors: Peter T. Bell, Timothy Baird, John Goddard, Olusola S. Olagoke, Andrew Burke, Shradha Subedi, Tiana R. Davey, James Anderson, Derek S. Sarovich, Erin P. Price
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:Microbiology Spectrum
Subjects:
empyema
metagenomics
high-throughput sequencing
parapneumonic effusion
pleural infection
microbiome
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01960-24
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https://journals.asm.org/doi/10.1128/spectrum.01960-24

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