Study Design and Baseline Characteristics of ALIGN, a Randomized Controlled Study of Atrasentan in Patients With IgA Nephropathy

Study Design and Baseline Characteristics of ALIGN, a Randomized Controlled Study of Atrasentan in Patients With IgA Nephropathy

Introduction: Endothelin A (ETA) receptor activation is a driver of proteinuria, kidney inflammation, and fibrosis in IgA nephropathy (IgAN). Atrasentan, a selective ETA receptor antagonist, has potential to reduce proteinuria and preserve kidney function in IgAN. ALIGN (NCT04573478) is a phase 3, r...

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Main Authors: Hiddo J.L. Heerspink, Meg Jardine, Donald E. Kohan, Richard A. Lafayette, Adeera Levin, Adrian Liew, Hong Zhang, Irene Noronha, Hernan Trimarchi, Fan Fan Hou, Ronny Renfurm, Todd Gray, Marianne Camargo, Jonathan Barratt
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Kidney International Reports
Subjects:
atrasentan
endothelin receptor antagonist
IgA nephropathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024924019624
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