Human umbilical cord mesenchymal stem cell-derived microvesicles alleviate pulmonary fibrosis by inhibiting monocyte‒macrophage migration through ERK1/2 signaling-mediated suppression of CCL2 expression

Human umbilical cord mesenchymal stem cell-derived microvesicles alleviate pulmonary fibrosis by inhibiting monocyte‒macrophage migration through ERK1/2 signaling-mediated suppression of CCL2 expression

Abstract Background Pulmonary fibrosis (PF) is a disease with high morbidity and mortality rates, but effective treatment options are extremely limited. Mesenchymal stem cells (MSCs) and their derivatives show promise as potential therapeutics for PF. However, the underlying mechanisms responsible f...

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Main Authors: Xiuping Liang, Yanhong Li, Yinlan Wu, Tong Wu, Deying Huang, Ziyi Tang, Lu Cheng, Chunyu Tan, Ronghui Liao, Jing Zhao, Zehui Liao, Yubin Luo, Yi Liu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Pulmonary fibrosis
Microvesicles derived from human umbilical cord mesenchymal stem cells
Monocyte–macrophages
CCL2/CCR2
ERK1/2
Online Access:https://doi.org/10.1186/s13287-025-04266-w
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https://doi.org/10.1186/s13287-025-04266-w

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