Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer

Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer

Summary: Castration-resistant prostate cancer (CRPC) remains an incurable disease in need of improved treatments. CAMKK2 is an emerging therapeutic target whose oncogenic effects in prostate cancer have, to date, been largely attributed to its activation of AMP-activated protein kinase (AMPK). Here,...

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Main Authors: Chenchu Lin, Thomas L. Pulliam, Jenny J. Han, Jiaqian Xu, Carlos Vera Recio, Sandi R. Wilkenfeld, Yan Shi, Manoj Kushwaha, Sarah Bench, Eduardo Ruiz, Sanjanaa Senthilkumar, Jayasurya Dileep, Peter D.A. Shepherd, Nora M. Navone, Albert R. Klekers, Elizabeth M. Whitley, Michael M. Ittmann, Livia S. Eberlin, Wenyi Wang, Daniel E. Frigo
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005637
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