The Role of ABCB1, ABCG2, and SLC Transporters in Pharmacokinetic Parameters of Selected Drugs and Their Involvement in Drug–Drug Interactions

The Role of ABCB1, ABCG2, and SLC Transporters in Pharmacokinetic Parameters of Selected Drugs and Their Involvement in Drug–Drug Interactions

Membrane transporters are expressed in a wide range of tissues in the human organism. These proteins regulate the penetration of various substances such as simple ions, xenobiotics, and an extensive number of therapeutics. ABC and SLC drug transporters play a crucial role in drug absorption, distrib...

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Bibliographic Details
Main Authors: Kajetan Kiełbowski, Małgorzata Król, Estera Bakinowska, Andrzej Pawlik
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Membranes
Subjects:
drug transporters
ATP binding cassette transporters
solute carrier transporters
p-glycoprotein
drug–drug interactions
Online Access:https://www.mdpi.com/2077-0375/14/11/223
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