RNA modifications in cancer
Abstract RNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such as N6‐methyladenosine (m6A) and 5‐methylcytosine (m5C), are implicated in various cellular processes. These modifications are regulated by proteins that write,...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | MedComm |
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| Online Access: | https://doi.org/10.1002/mco2.70042 |
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| _version_ | 1832594197024079872 |
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| author | Han Wu Shi Chen Xiang Li Yuyang Li He Shi Yiwen Qing Bohe Shi Yifei Tang Zhuoyi Yan Yang Hao Dongxu Wang Weiwei Liu |
| author_facet | Han Wu Shi Chen Xiang Li Yuyang Li He Shi Yiwen Qing Bohe Shi Yifei Tang Zhuoyi Yan Yang Hao Dongxu Wang Weiwei Liu |
| author_sort | Han Wu |
| collection | DOAJ |
| description | Abstract RNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such as N6‐methyladenosine (m6A) and 5‐methylcytosine (m5C), are implicated in various cellular processes. These modifications are regulated by proteins that write, erase, and read RNA and modulate RNA stability, splicing, translation, and degradation. Recent studies have highlighted their roles in metabolic reprogramming, signaling pathways, and cell cycle control, which are essential for tumor proliferation and survival. Despite these scientific advances, the precise mechanisms by which RNA modifications affect cancer remain inadequately understood. This review comprehensively examines the role RNA modifications play in cancer proliferation, metastasis, and programmed cell death, including apoptosis, autophagy, and ferroptosis. It explores their effects on epithelial–mesenchymal transition (EMT) and the immune microenvironment, particularly in cancer metastasis. Furthermore, RNA modifications’ potential in cancer therapies, including conventional treatments, immunotherapy, and targeted therapies, is discussed. By addressing these aspects, this review aims to bridge current research gaps and underscore the therapeutic potential of targeting RNA modifications to improve cancer treatment strategies and patient outcomes. |
| format | Article |
| id | doaj-art-2922b6b8e1b840e5bf93fb0232fa324e |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-2922b6b8e1b840e5bf93fb0232fa324e2025-01-20T01:45:44ZengWileyMedComm2688-26632025-01-0161n/an/a10.1002/mco2.70042RNA modifications in cancerHan Wu0Shi Chen1Xiang Li2Yuyang Li3He Shi4Yiwen Qing5Bohe Shi6Yifei Tang7Zhuoyi Yan8Yang Hao9Dongxu Wang10Weiwei Liu11Department of Oral and Maxillofacial SurgeryHospital of StomatologyJilin University, Changchun Jilin province ChinaDepartment of Oral and Maxillofacial SurgeryHospital of StomatologyJilin University, Changchun Jilin province ChinaDepartment of Oral and Maxillofacial SurgeryHospital of StomatologyJilin University, Changchun Jilin province ChinaDepartment of Oral and Maxillofacial SurgeryHospital of StomatologyJilin University, Changchun Jilin province ChinaDepartment of Oral and Maxillofacial SurgeryHospital of StomatologyJilin University, Changchun Jilin province ChinaDepartment of Oral and Maxillofacial SurgeryHospital of StomatologyJilin University, Changchun Jilin province ChinaLaboratory Animal CenterCollege of Animal ScienceJilin University, ChangchunJilin province ChinaLaboratory Animal CenterCollege of Animal ScienceJilin University, ChangchunJilin province ChinaLaboratory Animal CenterCollege of Animal ScienceJilin University, ChangchunJilin province ChinaLaboratory Animal CenterCollege of Animal ScienceJilin University, ChangchunJilin province ChinaLaboratory Animal CenterCollege of Animal ScienceJilin University, ChangchunJilin province ChinaDepartment of Oral and Maxillofacial SurgeryHospital of StomatologyJilin University, Changchun Jilin province ChinaAbstract RNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such as N6‐methyladenosine (m6A) and 5‐methylcytosine (m5C), are implicated in various cellular processes. These modifications are regulated by proteins that write, erase, and read RNA and modulate RNA stability, splicing, translation, and degradation. Recent studies have highlighted their roles in metabolic reprogramming, signaling pathways, and cell cycle control, which are essential for tumor proliferation and survival. Despite these scientific advances, the precise mechanisms by which RNA modifications affect cancer remain inadequately understood. This review comprehensively examines the role RNA modifications play in cancer proliferation, metastasis, and programmed cell death, including apoptosis, autophagy, and ferroptosis. It explores their effects on epithelial–mesenchymal transition (EMT) and the immune microenvironment, particularly in cancer metastasis. Furthermore, RNA modifications’ potential in cancer therapies, including conventional treatments, immunotherapy, and targeted therapies, is discussed. By addressing these aspects, this review aims to bridge current research gaps and underscore the therapeutic potential of targeting RNA modifications to improve cancer treatment strategies and patient outcomes.https://doi.org/10.1002/mco2.70042cancerimmune microenvironmentimmunotherapyprogrammed cell deathRNA modifications |
| spellingShingle | Han Wu Shi Chen Xiang Li Yuyang Li He Shi Yiwen Qing Bohe Shi Yifei Tang Zhuoyi Yan Yang Hao Dongxu Wang Weiwei Liu RNA modifications in cancer MedComm cancer immune microenvironment immunotherapy programmed cell death RNA modifications |
| title | RNA modifications in cancer |
| title_full | RNA modifications in cancer |
| title_fullStr | RNA modifications in cancer |
| title_full_unstemmed | RNA modifications in cancer |
| title_short | RNA modifications in cancer |
| title_sort | rna modifications in cancer |
| topic | cancer immune microenvironment immunotherapy programmed cell death RNA modifications |
| url | https://doi.org/10.1002/mco2.70042 |
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