T-bet overexpression enhances CAR T cell effector functions and antigen sensitivity

T-bet overexpression enhances CAR T cell effector functions and antigen sensitivity

Background T cells modified to express a chimeric antigen receptor (CAR) are successful against B-lineage malignancies but fail to induce durable remissions in up to half of patients and have shown limited efficacy against other types of cancer. Strategies to improve CAR T cell potency and responses...

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Bibliographic Details
Main Authors: M. Eric Kohler, Kole R DeGolier, Terry J Fry, Amalia M Rivera-Reyes, Jennifer M Cimons, Samuel D Burciaga, Michael C Yarnell, Amanda J Novak
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/4/e010962.full
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