The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability
Matrix metalloproteinase-9 (MMP-9) belongs to the MMP family and has been widely investigated. Excessive MMP-9 expression can enhance extracellular matrix degradation and promote plaque instability. Studies have demonstrated that MMP-9 levels are higher in vulnerable plaques than in stable plaques....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/3872367 |
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| _version_ | 1832560094287495168 |
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| author | Tiewei Li Xiaojuan Li Yichuan Feng Geng Dong Yuewu Wang Junmei Yang |
| author_facet | Tiewei Li Xiaojuan Li Yichuan Feng Geng Dong Yuewu Wang Junmei Yang |
| author_sort | Tiewei Li |
| collection | DOAJ |
| description | Matrix metalloproteinase-9 (MMP-9) belongs to the MMP family and has been widely investigated. Excessive MMP-9 expression can enhance extracellular matrix degradation and promote plaque instability. Studies have demonstrated that MMP-9 levels are higher in vulnerable plaques than in stable plaques. Additionally, several human studies have demonstrated that MMP-9 may be a predictor of atherosclerotic plaque instability and a risk factor for future adverse cardiovascular and cerebrovascular events. MMP-9 deficiency or blocking MMP-9 expression can inhibit plaque inflammation and prevent atherosclerotic plaque instability. All of these results suggest that MMP-9 may be a useful predictive biomarker for vulnerable atherosclerotic plaques, as well as a therapeutic target for preventing atherosclerotic plaque instability. In this review, we describe the structure, function, and regulation of MMP-9. We also discuss the role of MMP-9 in predicting and preventing atherosclerotic plaque instability. |
| format | Article |
| id | doaj-art-290df30f0abd43cdae2bcba85757b187 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-290df30f0abd43cdae2bcba85757b1872025-02-03T01:28:24ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/38723673872367The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque InstabilityTiewei Li0Xiaojuan Li1Yichuan Feng2Geng Dong3Yuewu Wang4Junmei Yang5Zhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, 33 Longhu Waihuan East Street, Jinshui District, Zhengzhou 450000, ChinaChildren’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, 33 Longhu Waihuan East Street, Jinshui District, Zhengzhou 450000, ChinaZhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, 33 Longhu Waihuan East Street, Jinshui District, Zhengzhou 450000, ChinaZhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, 33 Longhu Waihuan East Street, Jinshui District, Zhengzhou 450000, ChinaThe Engineering Research Center for New Drug Screening, Inner Mongolia Medical University, Hohhot, ChinaZhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, 33 Longhu Waihuan East Street, Jinshui District, Zhengzhou 450000, ChinaMatrix metalloproteinase-9 (MMP-9) belongs to the MMP family and has been widely investigated. Excessive MMP-9 expression can enhance extracellular matrix degradation and promote plaque instability. Studies have demonstrated that MMP-9 levels are higher in vulnerable plaques than in stable plaques. Additionally, several human studies have demonstrated that MMP-9 may be a predictor of atherosclerotic plaque instability and a risk factor for future adverse cardiovascular and cerebrovascular events. MMP-9 deficiency or blocking MMP-9 expression can inhibit plaque inflammation and prevent atherosclerotic plaque instability. All of these results suggest that MMP-9 may be a useful predictive biomarker for vulnerable atherosclerotic plaques, as well as a therapeutic target for preventing atherosclerotic plaque instability. In this review, we describe the structure, function, and regulation of MMP-9. We also discuss the role of MMP-9 in predicting and preventing atherosclerotic plaque instability.http://dx.doi.org/10.1155/2020/3872367 |
| spellingShingle | Tiewei Li Xiaojuan Li Yichuan Feng Geng Dong Yuewu Wang Junmei Yang The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability Mediators of Inflammation |
| title | The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability |
| title_full | The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability |
| title_fullStr | The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability |
| title_full_unstemmed | The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability |
| title_short | The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability |
| title_sort | role of matrix metalloproteinase 9 in atherosclerotic plaque instability |
| url | http://dx.doi.org/10.1155/2020/3872367 |
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