The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives

The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives

Aim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats. Methods and results. Compounds have been entered in a 1/10...

Full description

Saved in:

Bibliographic Details
Main Authors:	I. M. Bilay, E. O. Mihayluk, V. V. Parchenko, A. G. Kaplaushenko, A. I. Panasenko, E. G. Knysh
Format:	Article
Language:	English
Published:	Zaporizhzhia State Medical and Pharmaceutical University 2014-08-01
Series:	Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Subjects:	Pharmacological Actions Drug Screening Animal Experimental Toxic Hepatitis 1 4-triazole
Online Access:	http://pharmed.zsmu.edu.ua/article/view/26165/23623
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The average effective dose of 4-amino-5-(furan-2-yl)-4H-1 ,2,4-triazole-3-thiol in experimental hepatitis
by: I. M. Belay, et al.
Published: (2014-04-01)

Anticancer properties of 1,2,4-triazole derivatives (literature review)
by: I. V. Bushuieva, et al.
Published: (2024-06-01)

Pharmacological aspects of application of 1,2,4-triazole-3-thiol furan derivatives
by: O. A. Bihdan, et al.
Published: (2016-12-01)

Acute toxicity of S-derivatives of 4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles
by: O. A. Suhak, et al.
Published: (2017-12-01)

Discussion of antimicrobial and antifungal activity of 4-amino-5-methyl-4H-1,2,4-triazole-3-thiol
by: T. V. Kravchenko, et al.
Published: (2017-04-01)

The research of acute toxicity of 4-amino-5-(4-(tert-butyl)phenyl)-4H-1,2,4-triazoles-3-thiol derivatives
by: I. I. Аksyonova-Seliuk, et al.
Published: (2017-08-01)

Acute toxicity and "structure-action" dependence of 4-(R-benzylidenamino)-5-methyl-4H-1,2,4-triazoles 3-tion
by: T. V. Kravchenko, et al.
Published: (2017-08-01)

Acute toxicity of 2-(5-(adamantane-1-yl)-4R-1,2,4-triazole-3-ylthio) of the acetic acids and their salts’ derivatives
by: V. M. Odyntsova, et al.
Published: (2015-12-01)

ACUTE TOXICITYOF 4-AMINO-5-(2-, 3-, 4-NITROPHENYL)-1,2,4-TRIAZOLE-3-THIONES AND ITS DERIVATIVES
by: М. O. Shcherbak, et al.
Published: (2014-12-01)

Methods of synthesis of 1,2,4-triazole derivatives with methoxyphenyl and study the spectrum of their pharmacological activity
by: D. V. Dovbnia, et al.
Published: (2023-04-01)

The acute toxicity of 5-thio-substituted 3-(5-bromofuran-2-yl)-4-ethyl-(4H)-1,2,4-triazole derivatives
by: E. S. Pruglo, et al.
Published: (2015-08-01)

Study of the effect of sodium 2-((4-amino-5-(thiophen-2-ylmethyl)- 4H-1,2,4-triazole-3-yl)thio)acetate toxic doses on rats heart tissue
by: A. A. Safonov, et al.
Published: (2024-06-01)

The study of antimicrobial activity of 2-((4-R-3-(morpholinomethylene)-4H-1,2,4-triazole-5-yl)thio)acetic acid salts
by: R. О. Shcherbyna, et al.
Published: (2016-08-01)

Acute toxicity of 5-(2-, 3-, 4-methoxyphenyl, (3,4,5-trimethoxyphenyl)-)-1,2,4-triazole-3-thiones and its thioderivatives
by: Yu. G. Samelyuk, et al.
Published: (2015-12-01)

Biological properties of the compounds formed by the combination of the 1,2,4-triazoles, furans and other functional substitutes
by: D. M. Danilchenko, et al.
Published: (2015-12-01)

Antimicrobial activity of new 5-(furan-2-yl)-4-amino-1,2,4-triazole-3-thiol derivatives
by: D. M. Danilchenko, et al.
Published: (2017-02-01)

Acute toxicity of 5-(furan-2-yl, 2-metylfuran-3-yl)-4-amino-1,2,4-triazole-3-thiol alkyl derivatives
by: D. M. Danilchenko, et al.
Published: (2017-09-01)

Acute toxicity of 3-(2-, 3-fluorophenyl)-6-(aryl-, hetaryl)-[1,2,4]triazole[3,4-b][1,3,4]thiadiazoles
by: O. A. Bihdan, et al.
Published: (2017-12-01)

Heterocyclization reactions study of 3-thio and 3-thio-4-amino derivatives of 1,2,4–triazole
by: O. A. Bihdan, et al.
Published: (2017-04-01)

Analgesic activity of 4-amino-5-methyl-4H-1,2,4-triazol-3-thiones
by: T. V. Kravchenko, et al.
Published: (2018-10-01)

Diuretic activity of some 4- and 3-thio-substituted 1,2,4-triazoles with fluorophenyl fragments
by: O. A. Bihdan, et al.
Published: (2023-07-01)

In silico study of new bis-3R, 4R′-5-(((1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thione derivatives
by: Ye. O. Karpun, et al.
Published: (2019-12-01)

Computer prediction of toxicity of new S-alkyl derivatives of 1,2,4-triazole
by: V. V. Kalchenko, et al.
Published: (2024-11-01)

Synthesis and physical-chemical properties of 3-alkylthio-5-(quinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R-2,4-dihydro-3H-1,2,4-triazoles
by: T. M. Kaplaushenko, et al.
Published: (2016-06-01)

Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiol
by: I. I. Aksionova, et al.
Published: (2015-08-01)

Chemical properties of amino- and thio-derivatives of 1,2,4-triazoles
by: A. G. Kaplaushenko
Published: (2015-04-01)

Study of acute toxicity of new thiophene-containing derivatives of 1,2,4-triazole
by: A. V. Khilkovets, et al.
Published: (2023-03-01)

Computer prediction of acute toxicity of thioderivatives of 3,5-bis(5-mercapto-4-R-4H-1,2,4-triazol-3-yl)phenol
by: K. K. Isaicheva, et al.
Published: (2024-11-01)

Antihypoxic activity of benzylidenhydrazides of 4-R-5- (thiophene-2-ylmethyl)-1,2,4-triazol-3-il)thioacetic acid
by: O. A. Suhak, et al.
Published: (2017-08-01)

The search of new biologically active compounds with antibacterial and antifungal activity among 1,2,4-triazole-3-thiol derivatives with the remnants of thiophene
by: V. O. Salionov, et al.
Published: (2017-08-01)

Synthesis methods of 1,2,4-triazole-3-thiones: review
by: Yu. S. Frolova, et al.
Published: (2024-06-01)

Research of the antimicrobial and antifungal activity of 7-((3-thio-4-R-4H-1,2,4-triazoles-3-yl)methyl)theophylline S-derivatives
by: A. S. Gotsulya Ye. G. Knysh, et al.
Published: (2015-08-01)

Synthesis and investigation of the physicochemical properties of 2-(5-((theophylline-7'-yl)methyl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)-acetic acid salts
by: A. S. Gotsulya, et al.
Published: (2014-02-01)

The research of ammonium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate (PKR-177) influence on biochemical indices in rats blood under hepatitis initiated by tetrachloride methane
by: R. О. Shcherbyna, et al.
Published: (2017-12-01)

Anti-inflammatory activity of 2-(5-((theophylline-7'-yl)methyl)-4-R-4H-1,2,4-triazole-3-ylthio)acetic acid salts
by: A. S. Gotsulya, et al.
Published: (2014-12-01)

Synthesis and acute toxicity of new S-derivatives (1,2,4-triazole-3(2H)-yl)methyl) thiopyrimidines
by: Yu. V. Karpenko, et al.
Published: (2023-07-01)

Synthesis, physical and chemical properties, antihypoxic activity of some 5-[((5-(adamantane-1-yl)-4-R-4H-1,2,4-triazole-3-yl)thio)methyl]-N-R1-1,3,4-thiadiazole-2-amines and 5-[((5-(adamantane-1-yl)-4-R-4H-1,2,4-triazole-3-yl)thio)methyl]-4-R1-4H-1,2,4-t
by: V. M. Odyntsova, et al.
Published: (2018-03-01)

Synthesis and physical-chemical properties of 3-(4-(tert-butyl)phenyl)-5-(R-ylthio)-4H-1,2,4-triazol-4-amines
by: I. I. Aksyonova, et al.
Published: (2016-04-01)

Analysis of biological properties of 1,2,4-triazole-containing compounds (literature review)
by: A. V. Khilkovets, et al.
Published: (2022-04-01)

Analysis of the domestic market of 1,2,4-triazole-containing drugs
by: M. V. Ohloblina, et al.
Published: (2022-08-01)