Malondialdehyde in benign prostate hypertrophy: a useful marker?
Benign prostate hypertrophy (BPH) is the most common benign tumor in men due to obstruction of the urethra and, finally, uremia. Malondialdehyde (MDA) is a product derived from peroxidation of polyunsaturated fatty acids and related esters. Evaluation of MDA in serum represents a non-invasive biomar...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Mediators of Inflammation |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0962935031000097745 |
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| author | Rosaria Alba Merendino Francesco Salvo Antonella Saija Giuseppe Di Pasquale Antonio Tomaino Paola Lucia Minciullo Giuseppe Fraccica Sebastiano Gangemi |
| author_facet | Rosaria Alba Merendino Francesco Salvo Antonella Saija Giuseppe Di Pasquale Antonio Tomaino Paola Lucia Minciullo Giuseppe Fraccica Sebastiano Gangemi |
| author_sort | Rosaria Alba Merendino |
| collection | DOAJ |
| description | Benign prostate hypertrophy (BPH) is the most common benign tumor in men due to obstruction of the urethra and, finally, uremia. Malondialdehyde (MDA) is a product derived from peroxidation of polyunsaturated fatty acids and related esters. Evaluation of MDA in serum represents a non-invasive biomarker of oxidative stress. Prostate-specific antigen (PSA) is a sensitive marker for prostatic hypertrophy and cancer. We analyzed MDA serum levels to evaluate the oxidative stress in BPH. To this end, 22 BPH patients and 22 healthy donors were enrolled. Data show an increase of MDA level in BPH patients and a positive correlation between PSA and MDA levels. In conclusion, we describe a previously unknown relationship between PSA and MDA as an index of inflammation and oxidative stress in BPH. |
| format | Article |
| id | doaj-art-28d68f952d7a47faa5db9ef52c595c02 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-28d68f952d7a47faa5db9ef52c595c022025-02-03T05:50:07ZengWileyMediators of Inflammation0962-93511466-18612003-01-0112212712810.1080/0962935031000097745Malondialdehyde in benign prostate hypertrophy: a useful marker?Rosaria Alba Merendino0Francesco Salvo1Antonella Saija2Giuseppe Di Pasquale3Antonio Tomaino4Paola Lucia Minciullo5Giuseppe Fraccica6Sebastiano Gangemi7Chair of Immunopathology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, ItalySchool and Division of Urology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, ItalySchool of Pharmacy, Department Farmaco-Biologico, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, ItalyDepartment of Internal Medicine, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, ItalySchool of Pharmacy, Department Farmaco-Biologico, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, ItalySchool and Division of Allergy and Clinical Immunology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, ItalySchool and Division of Urology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, ItalySchool and Division of Allergy and Clinical Immunology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, ItalyBenign prostate hypertrophy (BPH) is the most common benign tumor in men due to obstruction of the urethra and, finally, uremia. Malondialdehyde (MDA) is a product derived from peroxidation of polyunsaturated fatty acids and related esters. Evaluation of MDA in serum represents a non-invasive biomarker of oxidative stress. Prostate-specific antigen (PSA) is a sensitive marker for prostatic hypertrophy and cancer. We analyzed MDA serum levels to evaluate the oxidative stress in BPH. To this end, 22 BPH patients and 22 healthy donors were enrolled. Data show an increase of MDA level in BPH patients and a positive correlation between PSA and MDA levels. In conclusion, we describe a previously unknown relationship between PSA and MDA as an index of inflammation and oxidative stress in BPH.http://dx.doi.org/10.1080/0962935031000097745Benign prostate hypertrophyMalondialdehydeProstate-specific antigen. |
| spellingShingle | Rosaria Alba Merendino Francesco Salvo Antonella Saija Giuseppe Di Pasquale Antonio Tomaino Paola Lucia Minciullo Giuseppe Fraccica Sebastiano Gangemi Malondialdehyde in benign prostate hypertrophy: a useful marker? Mediators of Inflammation Benign prostate hypertrophy Malondialdehyde Prostate-specific antigen. |
| title | Malondialdehyde in benign prostate hypertrophy: a useful marker? |
| title_full | Malondialdehyde in benign prostate hypertrophy: a useful marker? |
| title_fullStr | Malondialdehyde in benign prostate hypertrophy: a useful marker? |
| title_full_unstemmed | Malondialdehyde in benign prostate hypertrophy: a useful marker? |
| title_short | Malondialdehyde in benign prostate hypertrophy: a useful marker? |
| title_sort | malondialdehyde in benign prostate hypertrophy a useful marker |
| topic | Benign prostate hypertrophy Malondialdehyde Prostate-specific antigen. |
| url | http://dx.doi.org/10.1080/0962935031000097745 |
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