The role and clinical significance of tumor-associated macrophages in the epithelial–mesenchymal transition of lung cancer

Lung cancer remains the leading cause of cancer-related mortality worldwide. Tumor-associated macrophages (TAMs) and epithelial-mesenchymal transition (EMT) are key drivers of lung cancer metastasis and drug resistance. M2-polarized TAMs dominate the immunosuppressive tumor microenvironment (TME) an...

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Bibliographic Details
Main Authors: Lei Liao, Ying-Xia Wang, Su-Su Fan, Ying-Yue Hu, Xue-Chang Wang, Xuan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oncology
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Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1571583/full
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