Cross-sectional and longitudinal association of seven DNAm-based predictors with metabolic syndrome and type 2 diabetes

Cross-sectional and longitudinal association of seven DNAm-based predictors with metabolic syndrome and type 2 diabetes

Abstract Background To date, various epigenetic clocks have been constructed to estimate biological age, most commonly using DNA methylation (DNAm). These include “first-generation” clocks such as DNAmAgeHorvath and “second-generation” clocks such as DNAmPhenoAge and DNAmGrimAge. The divergence of o...

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Main Authors: Suet Mei Chew, Alexander Teumer, Pamela R. Matías‑García, Christian Gieger, Juliane Winckelmann, Karsten Suhre, Christian Herder, Wolfgang Rathmann, Annette Peters, Melanie Waldenberger
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Clinical Epigenetics
Subjects:
Epigenetic age acceleration
DNAm age
Metabolic syndrome
Diabetes
Risk prediction
Online Access:https://doi.org/10.1186/s13148-025-01862-8
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https://doi.org/10.1186/s13148-025-01862-8

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