Encapsulation of Nanocrystals in Mannitol-Based Inhalable Microparticles via Spray-Drying: A Promising Strategy for Lung Delivery of Curcumin

Encapsulation of Nanocrystals in Mannitol-Based Inhalable Microparticles via Spray-Drying: A Promising Strategy for Lung Delivery of Curcumin

Background/Objectives: Curcumin is well known for its great anti-inflammatory and antioxidant efficacy, representing a potential strategy for the treatment of respiratory disorders. However, several drawbacks, such as chemical instability, poor water solubility and rapid metabolism, result in low bi...

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Bibliographic Details
Main Authors: Luca Casula, Emanuela Fabiola Craparo, Eleonora Lai, Cinzia Scialabba, Donatella Valenti, Michele Schlich, Chiara Sinico, Gennara Cavallaro, Francesco Lai
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceuticals
Subjects:
nano into micro
nanosuspension
inhalable microparticles
curcumin
pulmonary delivery
Online Access:https://www.mdpi.com/1424-8247/17/12/1708
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