The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively.

The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively.

Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme of lipolysis. ATGL specifically hydrolyzes triacylglycerols (TGs), thereby generating diacylglycerols and free fatty acids. ATGL's enzymatic activity is co-activated by the protein comparative gene identification-58 (CGI-58) and inh...

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Main Authors: Irina Cornaciu, Andras Boeszoermenyi, Hanna Lindermuth, Harald M Nagy, Ines K Cerk, Catharina Ebner, Barbara Salzburger, Astrid Gruber, Martina Schweiger, Rudolf Zechner, Achim Lass, Robert Zimmermann, Monika Oberer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026349&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026349&type=printable

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