Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients
Background. Coronary atherosclerotic heart disease (CHD) is one of the major concerns in type 2 diabetes (T2D). The systemic chronic inflammation has been postulated to bridge the increased risk of cardiovascular disease and T2D. We formulated that increased peripheral proinflammatory T helper subse...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/596967 |
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| author | Ru-xing Zhao Wen-juan Li Yi-ran Lu Jun Qin Chuan-long Wu Meng Tian Tian-yi He Shou-nan Yi Dong-qi Tang Lei Sun Li Chen |
| author_facet | Ru-xing Zhao Wen-juan Li Yi-ran Lu Jun Qin Chuan-long Wu Meng Tian Tian-yi He Shou-nan Yi Dong-qi Tang Lei Sun Li Chen |
| author_sort | Ru-xing Zhao |
| collection | DOAJ |
| description | Background. Coronary atherosclerotic heart disease (CHD) is one of the major concerns in type 2 diabetes (T2D). The systemic chronic inflammation has been postulated to bridge the increased risk of cardiovascular disease and T2D. We formulated that increased peripheral proinflammatory T helper subsets contributed to the development of cardiovascular complications in diabetic patients. Methods. The frequencies of peripheral total CD4+ T helper cells, proinflammatory Th1, Th17, and Th22 subsets were determined by flow cytometry in diabetic patients with or without CHD (n=42 and 67, resp.). Results. Both peripheral frequencies and total numbers of Th1, Th17, and Th22 cells were further increased in diabetic patients with CHD. Logistic regression and categorical cross-table analysis further confirmed that increased proinflammatory Th subsets, especially Th22, were independent risk factors of cardiovascular complication in diabetes. Elevated Th subsets also correlated with increased CRP levels and the atherogenic index of plasma. Moreover, Th1 frequency and Th22 numbers demonstrated remarkable potential in predicting CHD in diabetes. Conclusions. Increased peripheral proinflammatory T helper subsets act in concert and contribute to the increased prevalence of diabetic cardiovasculopathy. The recently identified Th22 cells might play an independent role in CHD and represent a novel proxy for cardiovascular risks in diabetes. |
| format | Article |
| id | doaj-art-28a0d350daec463baf36f7d55d2d71d4 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-28a0d350daec463baf36f7d55d2d71d42025-02-03T01:12:10ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/596967596967Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic PatientsRu-xing Zhao0Wen-juan Li1Yi-ran Lu2Jun Qin3Chuan-long Wu4Meng Tian5Tian-yi He6Shou-nan Yi7Dong-qi Tang8Lei Sun9Li Chen10Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, ChinaCentre for Transplant and Renal Research, Westmead Millennium Institute, The University of Sydney at Westmead Hospital, Westmead, NSW, AustraliaKey Laboratory of Cardiovascular Remodeling and Function Research, Research Center for Cell Therapy, Qilu Hospital of Shandong University, Jinan 250000, ChinaDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, ChinaBackground. Coronary atherosclerotic heart disease (CHD) is one of the major concerns in type 2 diabetes (T2D). The systemic chronic inflammation has been postulated to bridge the increased risk of cardiovascular disease and T2D. We formulated that increased peripheral proinflammatory T helper subsets contributed to the development of cardiovascular complications in diabetic patients. Methods. The frequencies of peripheral total CD4+ T helper cells, proinflammatory Th1, Th17, and Th22 subsets were determined by flow cytometry in diabetic patients with or without CHD (n=42 and 67, resp.). Results. Both peripheral frequencies and total numbers of Th1, Th17, and Th22 cells were further increased in diabetic patients with CHD. Logistic regression and categorical cross-table analysis further confirmed that increased proinflammatory Th subsets, especially Th22, were independent risk factors of cardiovascular complication in diabetes. Elevated Th subsets also correlated with increased CRP levels and the atherogenic index of plasma. Moreover, Th1 frequency and Th22 numbers demonstrated remarkable potential in predicting CHD in diabetes. Conclusions. Increased peripheral proinflammatory T helper subsets act in concert and contribute to the increased prevalence of diabetic cardiovasculopathy. The recently identified Th22 cells might play an independent role in CHD and represent a novel proxy for cardiovascular risks in diabetes.http://dx.doi.org/10.1155/2014/596967 |
| spellingShingle | Ru-xing Zhao Wen-juan Li Yi-ran Lu Jun Qin Chuan-long Wu Meng Tian Tian-yi He Shou-nan Yi Dong-qi Tang Lei Sun Li Chen Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients Mediators of Inflammation |
| title | Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients |
| title_full | Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients |
| title_fullStr | Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients |
| title_full_unstemmed | Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients |
| title_short | Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients |
| title_sort | increased peripheral proinflammatory t helper subsets contribute to cardiovascular complications in diabetic patients |
| url | http://dx.doi.org/10.1155/2014/596967 |
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