Clonal expansion and diversification of germinal center and memory B cell responses to booster immunization in primates

Clonal expansion and diversification of germinal center and memory B cell responses to booster immunization in primates

Summary: Effective vaccines elicit B cell clonal expansion in germinal centers (GCs) that produce memory B cells and antibody-secreting plasma cells. In mice, memory B cells rarely re-enter GCs upon boosting and instead differentiate into plasma cells. However, mouse circulating memory constitutes o...

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Bibliographic Details
Main Authors: Lachlan P. Deimel, Yoshiaki Nishimura, Gabriela S. Silva Santos, Viren A. Baharani, Brianna Hernandez, Thiago Y. Oliveira, Andrew J. MacLean, Marie Canis, Sadman Shawraz, Anna Gazumyan, Harald Hartweger, Paul D. Bieniasz, Theodora Hatziioannou, Malcolm A. Martin, Michel C. Nussenzweig
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725009131
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http://www.sciencedirect.com/science/article/pii/S2211124725009131

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