Dysregulated type I/III interferon system in circulation from patients with anti-MDA5-positive dermatomyositis

Dysregulated type I/III interferon system in circulation from patients with anti-MDA5-positive dermatomyositis

Abstract Anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (DM) is often complicated by rapidly progressive interstitial lung disease (RP-ILD), leading to early mortality. Previous studies on the pathogenesis of anti-MDA5-positive DM highlighted type I interferons (IFNs...

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Main Authors: Akira Yoshida, Takahisa Gono, Yuka Okazaki, Masumi Shimizu, Yutaka Igarashi, Yoshihiro Kitahara, Tomoyuki Fujisawa, Takafumi Suda, Shoji Yokobori, Rimpei Morita, Masataka Kuwana
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Dermatomyositis
Interstitial lung disease
Autoantibodies
MDA5
Interferon lambda
NK cells
Online Access:https://doi.org/10.1038/s41598-025-10895-1
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https://doi.org/10.1038/s41598-025-10895-1

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