Influence of ABCB1 polymorphisms on aripiprazole and dehydroaripiprazole plasma concentrations

Influence of ABCB1 polymorphisms on aripiprazole and dehydroaripiprazole plasma concentrations

Abstract Aripiprazole (ARI) is an atypical antipsychotic which is a substrate of P-glycoprotein (P-gp), a transmembrane glycoprotein that plays a crucial role in eliminating potentially harmful compounds from the organism. ARI once-monthly (AOM) is a long-acting injectable form which improves treatm...

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Main Authors: Francisco José Toja-Camba, María Vidal-Millares, María José Durán-Maseda, Gonzalo Hermelo-Vidal, Ángel Carracedo, Olalla Maroñas, Luis Ramudo-Cela, Irene Zarra-Ferro, Anxo Fernández-Ferreiro, Cristina Mondelo-García
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
P-glycoprotein
Aripiprazole
Dehydroaripiprazole
Pharmacogenetics
Pharmacokinetics
Online Access:https://doi.org/10.1038/s41598-024-84192-8
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https://doi.org/10.1038/s41598-024-84192-8

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