Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery
Introduction: Natural killer (NK) cell activity (NKA) is downregulated in patients with colorectal cancer (CRC), and its dysfunction is possibly associated with increased risk of recurrence. However, its role in prognosis of CRC remains unclear. Prior research has shown that surgical stress can supp...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523324003243 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591826292310016 |
|---|---|
| author | Jeng-Fu You Cheng-Chi Lee Yun-Shien Lee Yih-Jong Chern Chun-Kai Liao Hung-Chih Hsu |
| author_facet | Jeng-Fu You Cheng-Chi Lee Yun-Shien Lee Yih-Jong Chern Chun-Kai Liao Hung-Chih Hsu |
| author_sort | Jeng-Fu You |
| collection | DOAJ |
| description | Introduction: Natural killer (NK) cell activity (NKA) is downregulated in patients with colorectal cancer (CRC), and its dysfunction is possibly associated with increased risk of recurrence. However, its role in prognosis of CRC remains unclear. Prior research has shown that surgical stress can suppress NKA. This study explores the relationship between NK cell/NKA and clinicopathological factors during the perioperative period in patients with CRC. Methods: We prospectively enrolled 45 patients with CRC. Venous blood samples were collected preoperatively and on postoperative day 3 (POD3) and 30 (POD30). NKA was assessed by measuring the plasma levels of NK cell-secreted IFN-γ. Results: NKA was significantly reduced on POD3 compared with baseline levels before surgery but showed significant recovery by POD30. NKA on POD30 was considerably higher in patients with advanced disease stages or one or more high-risk preoperative factors. Additionally, a higher NKA recovery in patients with advanced stage exhibited improved recurrence-free survival (RFS) and progression-free survival (PFS) (hazards ratio (HR): 0.2442). Furthermore, an increased percentage of CD56bright NK cells and a higher CD56bright/CD56dim NK cell ratio postoperatively on POD30 were associated with better RFS/PFS (HR: 0.2732, P = 0.0433 and HR: 0.2193, P = 0.024, respectively). Conclusions: Our findings indicate that a notable postoperative increase in CD56bright NK cells on POD30, both in percentage and ratio, correlates with a more favorable prognosis in CRC patients. Additionally, higher recovery rates of NKA in patients with advanced stages may offer potential applications in risk stratification and the development of treatment strategies for CRC. |
| format | Article |
| id | doaj-art-282d85d219bd4510a5c6e66a322e5851 |
| institution | Kabale University |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-282d85d219bd4510a5c6e66a322e58512025-01-22T05:41:22ZengElsevierTranslational Oncology1936-52332025-02-0152102198Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgeryJeng-Fu You0Cheng-Chi Lee1Yun-Shien Lee2Yih-Jong Chern3Chun-Kai Liao4Hung-Chih Hsu5Department of Colon and Rectal Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Neurosurgery, Linkou Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Biotechnology, Ming Chuan University, Taoyuan, TaiwanDepartment of Colon and Rectal Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Colon and Rectal Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Hematology-Oncology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; Corresponding author at: Division of Hematology-Oncology, Linkou Chang Gung Memorial Hospital, No. 5, Fu-Hsing Str., Guishan Dist., Taoyuan City 333, Taiwan.Introduction: Natural killer (NK) cell activity (NKA) is downregulated in patients with colorectal cancer (CRC), and its dysfunction is possibly associated with increased risk of recurrence. However, its role in prognosis of CRC remains unclear. Prior research has shown that surgical stress can suppress NKA. This study explores the relationship between NK cell/NKA and clinicopathological factors during the perioperative period in patients with CRC. Methods: We prospectively enrolled 45 patients with CRC. Venous blood samples were collected preoperatively and on postoperative day 3 (POD3) and 30 (POD30). NKA was assessed by measuring the plasma levels of NK cell-secreted IFN-γ. Results: NKA was significantly reduced on POD3 compared with baseline levels before surgery but showed significant recovery by POD30. NKA on POD30 was considerably higher in patients with advanced disease stages or one or more high-risk preoperative factors. Additionally, a higher NKA recovery in patients with advanced stage exhibited improved recurrence-free survival (RFS) and progression-free survival (PFS) (hazards ratio (HR): 0.2442). Furthermore, an increased percentage of CD56bright NK cells and a higher CD56bright/CD56dim NK cell ratio postoperatively on POD30 were associated with better RFS/PFS (HR: 0.2732, P = 0.0433 and HR: 0.2193, P = 0.024, respectively). Conclusions: Our findings indicate that a notable postoperative increase in CD56bright NK cells on POD30, both in percentage and ratio, correlates with a more favorable prognosis in CRC patients. Additionally, higher recovery rates of NKA in patients with advanced stages may offer potential applications in risk stratification and the development of treatment strategies for CRC.http://www.sciencedirect.com/science/article/pii/S1936523324003243CD56bright natural killer cellColorectal cancerPrognosisNK cell activitysurgery |
| spellingShingle | Jeng-Fu You Cheng-Chi Lee Yun-Shien Lee Yih-Jong Chern Chun-Kai Liao Hung-Chih Hsu Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery Translational Oncology CD56bright natural killer cell Colorectal cancer Prognosis NK cell activity surgery |
| title | Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery |
| title_full | Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery |
| title_fullStr | Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery |
| title_full_unstemmed | Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery |
| title_short | Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery |
| title_sort | prognostic significance of perioperative circulating cd56bright nk cell and recovery of nk cell activity in patients with colorectal cancer undergoing radical surgery |
| topic | CD56bright natural killer cell Colorectal cancer Prognosis NK cell activity surgery |
| url | http://www.sciencedirect.com/science/article/pii/S1936523324003243 |
| work_keys_str_mv | AT jengfuyou prognosticsignificanceofperioperativecirculatingcd56brightnkcellandrecoveryofnkcellactivityinpatientswithcolorectalcancerundergoingradicalsurgery AT chengchilee prognosticsignificanceofperioperativecirculatingcd56brightnkcellandrecoveryofnkcellactivityinpatientswithcolorectalcancerundergoingradicalsurgery AT yunshienlee prognosticsignificanceofperioperativecirculatingcd56brightnkcellandrecoveryofnkcellactivityinpatientswithcolorectalcancerundergoingradicalsurgery AT yihjongchern prognosticsignificanceofperioperativecirculatingcd56brightnkcellandrecoveryofnkcellactivityinpatientswithcolorectalcancerundergoingradicalsurgery AT chunkailiao prognosticsignificanceofperioperativecirculatingcd56brightnkcellandrecoveryofnkcellactivityinpatientswithcolorectalcancerundergoingradicalsurgery AT hungchihhsu prognosticsignificanceofperioperativecirculatingcd56brightnkcellandrecoveryofnkcellactivityinpatientswithcolorectalcancerundergoingradicalsurgery |