High intake of n-6 polyunsaturated fatty acid exacerbates non-alcoholic steatohepatitis by the involvement of multiple metabolic pathways

High intake of n-6 polyunsaturated fatty acid exacerbates non-alcoholic steatohepatitis by the involvement of multiple metabolic pathways

Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, inflammation, and hepatocyte damage. A Western-style diet characterized by excessive n-6 polyunsaturated fatty acid (n-6 PUFA) intake, which is metabolized to pro-inflammatory arachidonic acids (AAs), might contribute to the exacerb...

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Main Authors: Jian-Tong, Meng-Ting Zhou, Xiang-Zhun Song, Liu Yang, Yu-Hui Fang, Lan Liu, Jing-Shu Cui, Xiao-Chen Lu, Hai-Yang Zhu, Ying-Bin Jin, Hong-Mei Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Nutrition
Subjects:
n-6 polyunsaturated fatty acids
non-alcoholic steatohepatitis
choline deficiency
arachidonic acid
leukotrienes
lipoxygenase pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1562509/full
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https://www.frontiersin.org/articles/10.3389/fnut.2025.1562509/full

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