Gestational hypercholanemia suppresses pregnancy‐associated adipose mass increase and stimulates a pro‐inflammatory environment in mice

Gestational hypercholanemia suppresses pregnancy‐associated adipose mass increase and stimulates a pro‐inflammatory environment in mice

Abstract Women with intrahepatic cholestasis of pregnancy (ICP) have hypercholanemia alongside an increased risk of dyslipidemia. We investigated how cholic acid (CA) supplementation in murine pregnancy impacts adipose tissue function. Mice were fed normal or 0.5% CA‐supplemented chow from identific...

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Main Authors: Vanya Nikolova, Alice L. Mitchell, Elena Bellafante, Eugene Jansen, Georgia Papacleovoulou, Per‐Olof Bergh, Hanns‐Ulrich Marshall, Catherine Williamson
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Physiological Reports
Subjects:
adipocyte
fetal growth restriction
hypercholanemia
hyperlipidemia
intrahepatic cholestasis of pregnancy
Online Access:https://doi.org/10.14814/phy2.70141
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https://doi.org/10.14814/phy2.70141

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