Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease

Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease

Abstract Background and Objective Mitochondria are crucial to the function of renal tubular cells, and their dynamic perturbation in many aspects is an important mechanism of diabetic kidney disease (DKD). Single-nucleus RNA sequencing (snRNA-seq) technology is a high-throughput sequencing analysis...

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Bibliographic Details
Main Authors: Zhen Zhu, Guangxin Luan, Song Wu, Yiyi Song, Shuang Shen, Kaiyue Wu, Shengnan Qian, Weiping Jia, Jun Yin, Tao Ren, Jianping Ye, Li Wei
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
snRNA-seq
Mitophagy
Mitochondrial homeostasis perturbation
Diabetic kidney disease
Losartan
Online Access:https://doi.org/10.1186/s12967-025-06074-5
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https://doi.org/10.1186/s12967-025-06074-5

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