An Overview of DNA Repair in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is an adult onset neurodegenerative disorder characterised by the degeneration of cortical and spinal cord motor neurons, resulting in progressive muscular weakness and death. Increasing evidence supports mitochondrial dy...
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| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2011/853474 |
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| _version_ | 1832559335756005376 |
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| author | Fabio Coppedè |
| author_facet | Fabio Coppedè |
| author_sort | Fabio Coppedè |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is an adult onset neurodegenerative disorder characterised by the degeneration of cortical and spinal cord motor neurons, resulting in progressive muscular weakness and death. Increasing evidence supports mitochondrial dysfunction and oxidative DNA damage in ALS motor neurons. Several DNA repair enzymes are activated following DNA damage to restore genome integrity, and impairments in DNA repair capabilities could contribute to motor neuron degeneration. After a brief description of the evidence of DNA damage in ALS, this paper focuses on the available data on DNA repair activity in ALS neuronal tissue and disease animal models. Moreover, biochemical and genetic data on DNA repair in ALS are discussed in light of similar findings in other neurodegenerative diseases. |
| format | Article |
| id | doaj-art-27f63e75fd494d7189b8b81e622cc38b |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-27f63e75fd494d7189b8b81e622cc38b2025-02-03T01:30:15ZengWileyThe Scientific World Journal1537-744X2011-01-01111679169110.1100/2011/853474853474An Overview of DNA Repair in Amyotrophic Lateral SclerosisFabio Coppedè0Section of Medical Genetics, Faculty of Medicine, University of Pisa, Via S. Giuseppe 22, 56126 Pisa, ItalyAmyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is an adult onset neurodegenerative disorder characterised by the degeneration of cortical and spinal cord motor neurons, resulting in progressive muscular weakness and death. Increasing evidence supports mitochondrial dysfunction and oxidative DNA damage in ALS motor neurons. Several DNA repair enzymes are activated following DNA damage to restore genome integrity, and impairments in DNA repair capabilities could contribute to motor neuron degeneration. After a brief description of the evidence of DNA damage in ALS, this paper focuses on the available data on DNA repair activity in ALS neuronal tissue and disease animal models. Moreover, biochemical and genetic data on DNA repair in ALS are discussed in light of similar findings in other neurodegenerative diseases.http://dx.doi.org/10.1100/2011/853474 |
| spellingShingle | Fabio Coppedè An Overview of DNA Repair in Amyotrophic Lateral Sclerosis The Scientific World Journal |
| title | An Overview of DNA Repair in Amyotrophic Lateral Sclerosis |
| title_full | An Overview of DNA Repair in Amyotrophic Lateral Sclerosis |
| title_fullStr | An Overview of DNA Repair in Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | An Overview of DNA Repair in Amyotrophic Lateral Sclerosis |
| title_short | An Overview of DNA Repair in Amyotrophic Lateral Sclerosis |
| title_sort | overview of dna repair in amyotrophic lateral sclerosis |
| url | http://dx.doi.org/10.1100/2011/853474 |
| work_keys_str_mv | AT fabiocoppede anoverviewofdnarepairinamyotrophiclateralsclerosis AT fabiocoppede overviewofdnarepairinamyotrophiclateralsclerosis |