Safety and effectiveness of the early-onset sepsis calculator to reduce antibiotic exposure in at-risk newborns: a cluster-randomised controlled trialResearch in context

Safety and effectiveness of the early-onset sepsis calculator to reduce antibiotic exposure in at-risk newborns: a cluster-randomised controlled trialResearch in context

Summary: Background: Newborns are at risk for early-onset sepsis (EOS), occurring 0.2–2.0 per 1000 live births, and for antibiotic overtreatment: approximately 5–15% receive antibiotics for suspected EOS under conventional guidelines with categorical risk factor assessment. Use of the multivariate...

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Main Authors: Bo M. van der Weijden, Sanne W.C.M. Janssen, Marijke C. van der Weide, Renske J.P.M. Cornelisse-van Vugt, Gavin W. ten Tusscher, Claire A.M. Lutterman, Arvid W.A. Kamps, Carmen M. Lorente Flores, Jeroen Hol, Henriëtte van Laerhoven, Maarten Rijpert, Nadia A. Oeij, Irene A.M. Schiering, Sylvia A. Obermann-Borst, Douwe H. Visser, Lisanne M. van Leeuwen, René F. Kornelisse, Annemarie M.C. van Rossum, Merijn W. Bijlsma, Frans B. Plötz, Niek B. Achten
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:EClinicalMedicine
Subjects:
Early-onset sepsis calculator
Early-onset sepsis
EOS
Neonatal sepsis calculator
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025003517
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