Clinical and Radiological Findings in Patients with Newly Diagnosed Graves’ Ophthalmopathy
Background. Graves’ ophthalmopathy is the most common extrathyroidal manifestation of Graves’ disease. The objective of this study was to investigate the clinical ophthalmological and MRI findings in newly diagnosed Graves’ ophthalmopathy. Methods. This study included 36 newly diagnosed Graves’ dise...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/5513008 |
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| author | Yakup Cevik Hande Taylan Sekeroglu Burce Ozgen Kadriye Erkan Turan Ali Sefik Sanac |
| author_facet | Yakup Cevik Hande Taylan Sekeroglu Burce Ozgen Kadriye Erkan Turan Ali Sefik Sanac |
| author_sort | Yakup Cevik |
| collection | DOAJ |
| description | Background. Graves’ ophthalmopathy is the most common extrathyroidal manifestation of Graves’ disease. The objective of this study was to investigate the clinical ophthalmological and MRI findings in newly diagnosed Graves’ ophthalmopathy. Methods. This study included 36 newly diagnosed Graves’ disease patients and 23 control participants. Patients and control participants underwent detailed ophthalmologic examination. In addition, all subjects underwent orbital MRI examination; and sizes, cross-sectional areas, and signal intensities of extraocular muscles were also measured. Results. Based on MRI measurements, the mean exophthalmos in the left eye was significantly higher in the patient group when compared to those of controls (2.04 ± 0.29 vs. 1.85 ± 0.15 cm, p = 0.003). The mean long diameter of inferior oblique muscle in both the right and left eyes were significantly shorter in patients when compared to those of controls (p = 0.001, p = 0.002, resp.); however, the mean long diameter of superior oblique in the left eye was longer in patients than those of controls (p = 0.001). Patients had significantly higher superior oblique muscle signal intensity than those of controls in the right eye (p = 0.01). There was no significant difference for the other parameters between the patient and control groups. Conclusion. Our findings suggest that there is no obvious change in MRI examination despite clinical ophthalmological findings in patients with newly diagnosed Graves’ ophthalmopathy. Unnecessary MRI examination should be avoided in this patient group due to unsatisfactory cost-effectiveness. |
| format | Article |
| id | doaj-art-27bea7c6d08d4fcb85ec50ddc247df7c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-27bea7c6d08d4fcb85ec50ddc247df7c2025-02-03T06:43:33ZengWileyInternational Journal of Endocrinology1687-83371687-83452021-01-01202110.1155/2021/55130085513008Clinical and Radiological Findings in Patients with Newly Diagnosed Graves’ OphthalmopathyYakup Cevik0Hande Taylan Sekeroglu1Burce Ozgen2Kadriye Erkan Turan3Ali Sefik Sanac4Department of Ophthalmology, Nevsehir State Hospital, Nevsehir, TurkeyDepartment of Ophthalmology, Hacettepe University School of Medicine, Ankara, TurkeyDepartment of Radiology, The University of Illinois at Chicago, Chicago, IL, USAPrivate Practice, Ankara, TurkeyPrivate Practice, Ankara, TurkeyBackground. Graves’ ophthalmopathy is the most common extrathyroidal manifestation of Graves’ disease. The objective of this study was to investigate the clinical ophthalmological and MRI findings in newly diagnosed Graves’ ophthalmopathy. Methods. This study included 36 newly diagnosed Graves’ disease patients and 23 control participants. Patients and control participants underwent detailed ophthalmologic examination. In addition, all subjects underwent orbital MRI examination; and sizes, cross-sectional areas, and signal intensities of extraocular muscles were also measured. Results. Based on MRI measurements, the mean exophthalmos in the left eye was significantly higher in the patient group when compared to those of controls (2.04 ± 0.29 vs. 1.85 ± 0.15 cm, p = 0.003). The mean long diameter of inferior oblique muscle in both the right and left eyes were significantly shorter in patients when compared to those of controls (p = 0.001, p = 0.002, resp.); however, the mean long diameter of superior oblique in the left eye was longer in patients than those of controls (p = 0.001). Patients had significantly higher superior oblique muscle signal intensity than those of controls in the right eye (p = 0.01). There was no significant difference for the other parameters between the patient and control groups. Conclusion. Our findings suggest that there is no obvious change in MRI examination despite clinical ophthalmological findings in patients with newly diagnosed Graves’ ophthalmopathy. Unnecessary MRI examination should be avoided in this patient group due to unsatisfactory cost-effectiveness.http://dx.doi.org/10.1155/2021/5513008 |
| spellingShingle | Yakup Cevik Hande Taylan Sekeroglu Burce Ozgen Kadriye Erkan Turan Ali Sefik Sanac Clinical and Radiological Findings in Patients with Newly Diagnosed Graves’ Ophthalmopathy International Journal of Endocrinology |
| title | Clinical and Radiological Findings in Patients with Newly Diagnosed Graves’ Ophthalmopathy |
| title_full | Clinical and Radiological Findings in Patients with Newly Diagnosed Graves’ Ophthalmopathy |
| title_fullStr | Clinical and Radiological Findings in Patients with Newly Diagnosed Graves’ Ophthalmopathy |
| title_full_unstemmed | Clinical and Radiological Findings in Patients with Newly Diagnosed Graves’ Ophthalmopathy |
| title_short | Clinical and Radiological Findings in Patients with Newly Diagnosed Graves’ Ophthalmopathy |
| title_sort | clinical and radiological findings in patients with newly diagnosed graves ophthalmopathy |
| url | http://dx.doi.org/10.1155/2021/5513008 |
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