Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD

Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD

IntroductionSirtuin 1, a class III histone deacetylase, plays a critical role in the pathophysiology of both diabetes mellitus and bone metabolism by promoting osteoblast differentiation and inhibiting osteoclast maturation. However, its exact impact on bone mineral density (BMD) and bone metabolism...

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Main Authors: Yao Xu, Tianxiao Hu, Peiwu Jiang, Xiujing Wang, Jiaqi Yao, Huiling Shen, Zhenying Zhang, Bojing Zheng, Ting Wang, Yanxia Ren, Jing Wang, Qingying Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Endocrinology
Subjects:
Sirtuin 1
bone mineral density
bone turnover markers
type 2 diabetes mellitus
bone metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1480847/full
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https://www.frontiersin.org/articles/10.3389/fendo.2024.1480847/full

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