Heterologous Immunization with Improved HIV-1 Subtype C Vaccines Elicit Autologous Tier 2 Neutralizing Antibodies with Rapid Viral Replication Control After SHIV Challenge

Heterologous Immunization with Improved HIV-1 Subtype C Vaccines Elicit Autologous Tier 2 Neutralizing Antibodies with Rapid Viral Replication Control After SHIV Challenge

We previously reported on HIV vaccines that elicited autologous Tier 2 neutralizing antibodies (nAbs) in rabbits. In the current study, we sought to establish a proof of concept that HIV vaccines using identical designs elicit Tier 2 nAbs in arhesus macaque (RM) model. DNA and MVA vaccines expressin...

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Bibliographic Details
Main Authors: Gerald K. Chege, Rosamund E. Chapman, Alana T. Keyser, Craig H. Adams, Kealan Benn, Michiel T. van Diepen, Nicola Douglass, Bronwen Lambson, Tandile Hermanus, Penny L. Moore, Anna-Lise Williamson
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Viruses
Subjects:
immunogenicity
DNA vaccine
MVA vaccine
gp140 Env
SHIV
neutralization
Online Access:https://www.mdpi.com/1999-4915/17/2/277
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