Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity

Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity

Abstract Understanding the mechanisms of synaptic plasticity is crucial for elucidating how the brain adapts to internal and external stimuli. A key objective of plasticity is maintaining physiological activity states during perturbations by adjusting synaptic transmission through negative feedback...

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Bibliographic Details
Main Authors: Maximilian Lenz, Paul Turko, Pia Kruse, Amelie Eichler, Zhuo Angel Chen, Juri Rappsilber, Imre Vida, Andreas Vlachos
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Brain
Subjects:
homeostatic synaptic plasticity
organotypic tissue culture
transcriptome
proteomics
Online Access:https://doi.org/10.1186/s13041-024-01153-y
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https://doi.org/10.1186/s13041-024-01153-y

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