Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration

Enhancing TREM2 expression activates microglia and modestly mitigates tau pathology and neurodegeneration

Abstract TREM2, a microglia-specific receptor, is strongly associated with Alzheimer’s disease (AD) risk, mediating microglial responses to amyloid pathology critical to AD development. However, its role in tau pathology and neurodegeneration remains unclear. Using the PS19 tauopathy mouse model wit...

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Main Authors: Kai Chen, Fuyao Li, Shuwen Zhang, Yixing Chen, Tadafumi C. Ikezu, Zonghua Li, Yuka A. Martens, Wenhui Qiao, Axel Meneses, Yiyang Zhu, Gisela Xhafkollari, Guojun Bu, Na Zhao
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Neuroinflammation
Subjects:
TREM2
R47H variant
Microglia
Alzheimer’s disease
Tau pathology
Transcriptomics
Online Access:https://doi.org/10.1186/s12974-025-03420-8
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https://doi.org/10.1186/s12974-025-03420-8

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