Huaxian formula alleviates nickel oxide nanoparticle-induced pulmonary fibrosis via PI3K/AKT signaling

Huaxian formula alleviates nickel oxide nanoparticle-induced pulmonary fibrosis via PI3K/AKT signaling

Abstract As a progressive fibrotic lung disorder with high mortality, pulmonary fibrosis (PF) suffers from inadequate treatment options. While the traditional Chinese medicine (TCM) formulation Huaxian Formula (HXF) demonstrates multi-target therapeutic potential against PF, the identity of its acti...

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Bibliographic Details
Main Authors: Minmin Tian, Liruohan Feng, Mi Tian, Xiaodong Mu, Shi Bu, Jianfeng Liu, Jingyu Xie, Yujie Xie, Ling Hou, Guanghua Li
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Pulmonary fibrosis
Huaxian formula
PI3K/AKT pathway
Network Pharmacology
Experimental validation
Nickel oxide nanoparticles
Online Access:https://doi.org/10.1038/s41598-025-01899-y
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https://doi.org/10.1038/s41598-025-01899-y

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