Clinical application of nanopore sequencing for haplotype linkage analysis in preimplantation genetic testing for Duchenne muscular dystrophy

Clinical application of nanopore sequencing for haplotype linkage analysis in preimplantation genetic testing for Duchenne muscular dystrophy

Abstract Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscular dystrophy, ultimately leading to paralysis and death from cardiac failure and/or respiratory insufficiency. Preimplantation genetic testing for monogenic disorders (PGT-M) has proven ef...

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Bibliographic Details
Main Authors: Qiuping Xia, Tianli Chang, Taoli Ding, Zhen Liu, Jiaqi Liu, Yanping Li, Zhongyuan Yao
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Duchenne muscular dystrophy
Nanopore sequencing
Single-nucleotide polymorphisms
PGT-M
Preimplantation genetic testing
Online Access:https://doi.org/10.1038/s41598-025-16358-x
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https://doi.org/10.1038/s41598-025-16358-x

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